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HSD11B1 抗体 (N-Term)

Name: HSD11B1 抗体 (N-Term)
SKU: ABIN2773867
Availability: OutOfStock

This anti-HSD11B1 antibody is a 兔多克隆 antibody detecting HSD11B1 in WB 和 IHC. Suitable for 人, 大鼠, 小鼠, 犬, 兔, 绵羊, Cow, 马和豚鼠. This Primary Antibody has been cited in 2+ publications.

WB Suggested Anti-HSD11B1 Antibody Titration: 2 ug/ml Positive Control: Transient overexpression lysate of HSD11B1 and Non-overexpressed vector control lysate (HSD11B1 抗体 (N-Term))

Immunohistochemistry (IHC) image for anti-Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1) (N-Term) antibody (ABIN2773867) (HSD11B1 抗体 (N-Term))

IHC

Immunohistochemistry with Human Liver cell lysate tissue at an antibody concentration of 5. (HSD11B1 抗体 (N-Term))

IHC

WB Suggested Anti-HSD11B1 Antibody Titration: 1 ug/ml Positive Control: Fetal liver cell lysate (HSD11B1 抗体 (N-Term))

Host: Rat Target Name: HSD11B1 Sample Tissue: Rat Liver Antibody Dilution: 1ug/ml (HSD11B1 抗体 (N-Term))

5 images

(2 references)

产品编号 ABIN2773867

发货至: 中国

Datasheet as PDF

Quick Overview for HSD11B1 抗体 (N-Term) (ABIN2773867)

抗原

See all HSD11B1 抗体

HSD11B1 (Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1))

适用

人, 大鼠, 小鼠, 犬, 兔, 绵羊, Cow, 马, 豚鼠

宿主

兔

克隆类型

多克隆

标记

This HSD11B1 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC)

Discover our top product HSD11B1 Primary Antibody

抗原表位
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3

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2

1

1

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1

1

1

1
N-Term

序列

QKVVSHCLEL GAASAHYIAG TMEDMTFAEQ FVAQAGKLMG GLDMLILNHI

预测反应

Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Sheep: 93%

产品特性

This is a rabbit polyclonal antibody against HSD11B1. It was validated on Western Blot using a cell lysate as a positive control.

纯化方法

Affinity Purified

免疫原

The immunogen is a synthetic peptide directed towards the N terminal region of human HSD11B1
anti-Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1) (AA 201-292) antibody
HSD11B1 适用: 人, 大鼠, 小鼠, 马 ELISA, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated

anti-Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1) (Internal Region) antibody
HSD11B1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1) (AA 1-292) antibody
HSD11B1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2C10 unconjugated

anti-Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1) (C-Term) antibody
HSD11B1 适用: 人 WB, ICC, IHC (p), IF, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1) (AA 25-292) antibody
HSD11B1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1) (N-Term) antibody
HSD11B1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1) (AA 77-92) antibody
HSD11B1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1) (AA 1-292) antibody
HSD11B1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1) (AA 1-292) antibody
HSD11B1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated

anti-Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1) (N-Term) antibody
HSD11B1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilutions should be determined experimentally by the investigator.

说明

Antigen size: 292 AA

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Kuroda, Venkatakrishnan, Salker, Lucas, Shaheen, Kuroda, Blanks, Christian, Quenby, Brosens: "Induction of 11?-HSD 1 and activation of distinct mineralocorticoid receptor- and glucocorticoid receptor-dependent gene networks in decidualizing human endometrial stromal cells." in: Molecular endocrinology (Baltimore, Md.), Vol. 27, Issue 2, pp. 192-202, (2013) (PubMed).

Lei, Chen, Georgiou, Sooranna, Khanjani, Brosens, Bennett, Johnson: "Progesterone acts via the nuclear glucocorticoid receptor to suppress IL-1?-induced COX-2 expression in human term myometrial cells." in: PLoS ONE, Vol. 7, Issue 11, pp. e50167, (2012) (PubMed).
抗原

HSD11B1 (Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1))

别名

HSD11B1

背景

HSD11B1 is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, HSD11B1 can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children.The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene.
Alias Symbols: 11-DH, 11-beta-HSD1, HDL, HSD11, HSD11B, HSD11L, MGC13539, SDR26C1
Protein Interaction Partner: GKAP1, CD36,
Protein Size: 292

分子量

32 kDa

基因ID

3290

NCBI登录号

NM_005525, NP_005516

UniProt

P28845

途径

Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, Regulation of Carbohydrate Metabolic Process