TPBG 抗体
Quick Overview for TPBG 抗体 (ABIN2763610)
抗原
See all TPBG 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人
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产品特性
- Trophoblast glycoprotein, TPBG, 5T4 oncofetal antigen, 5T4 oncotrophoblast glycoprotein, 5T4 oncofetal trophoblast glycoprotein, M6P1,5T4 is a N-glycosylated transmembrane 72 kDa (420 AA) glycoprotein containing seven leucine-rich repeat regions. 5T4 is often referred to as an oncofetal antigen due to its expression in fetal trophoblast where it was first discovered or trophoblast glycoprotein (TPBG). 5T4 oncofetal antigen is defined by a monoclonal antibody originally raised against human placental trophoblast and which recognizes a 72 kD glycoprotein expressed in a variety of different carcinomas but detected only at very low levels in normal epithelia. Patterns of expression of 5T4 oncofetal antigen in colorectal carcinomas indicate a significant association with tumor metastasis. By IHC, 71 % of the carcinomas demonstrate positive 5T4 immunoreactivity in adenocarcinoma cells and/or associated stromal tissue.5T4 is found in tumors including the colorectal, ovarian, and gastric. Its expression is used as a prognostic aid in these cases. 5T4 is widespread in malignant tumors throughout the various stages of their development. In assessing the 5T4 phenotype it has been determined that there is a significant correlation between 5T4 expression and advanced stage of disease (FIGO stages III and IV) (P < 0.001) and with poorly differentiated tumors (P = 0.036) compared to well or moderately differentiated tumors. Patients with tumors expressing 5T4 were are likely to respond well to adjuvant therapy and have a significantly worse outlook in terms of survival and disease-free interval.
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纯化方法
- Antigen Immunoaffinity Purification
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免疫原
- Synthetic peptide derived from human 5T4 oncofetal antigen protein
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亚型
- Ig Fraction
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anti-Trophoblast Glycoprotein (TPBG) (AA 219-328) antibody
TPBG 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1B6 unconjugated
anti-Trophoblast Glycoprotein (TPBG) (AA 32-351) antibodyTPBG 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Trophoblast Glycoprotein (TPBG) (AA 34-356) antibodyTPBG 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Trophoblast Glycoprotein (TPBG) antibodyTPBG 适用: 人 WB, ELISA, IHC 宿主: 兔 Monoclonal 6E9 unconjugated Recombinant Antibody
anti-Trophoblast Glycoprotein (TPBG) (AA 1-420) antibodyTPBG 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Trophoblast Glycoprotein (TPBG) (AA 32-355) antibodyTPBG 适用: 人 ELISA, FACS 宿主: 兔 Monoclonal DM137 unconjugated
anti-Trophoblast Glycoprotein (TPBG) antibodyTPBG 适用: 人 ELISA, IHC 宿主: 兔 Monoclonal 1D4 unconjugated Recombinant Antibody
anti-Trophoblast Glycoprotein (TPBG) (AA 219-328) antibodyTPBG 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Trophoblast Glycoprotein (TPBG) (N-Term) antibodyTPBG 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Trophoblast Glycoprotein (TPBG) (AA 1-420) antibodyTPBG 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- This antibody can be used for immunohistochemistry on formalin/paraffin sections (5-10 μg/mL). Optimal concentration should be evaluated by serial dilutions.
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限制
- 仅限研究用
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缓冲液
- Provided as solution in phosphate buffered saline with 0.08 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
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- TPBG (Trophoblast Glycoprotein (TPBG))
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别名
- 5T4 Oncofetal Trophoblast glycoprotein
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UniProt
- Q13641
抗原
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