(1 reference)-
- 抗原
- CD158a/g/h
- 适用
- 人
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- 非结合性
- 应用范围
- Flow Cytometry (FACS), Immunoprecipitation (IP)
- 特异性
- The mouse monoclonal antibody HP-MA4 recognizes an extracellular epitope of CD158 isoforms KIR2DL1 (CD158a), KIR2DS5 (CD158g), KIR2DS1 (CD158h), and KIR2DS3. It does not recognize the isoforms CD158b1,d,f,i,j.
- 交叉反应 （详细）
- Human
- 纯化方法
- Purified by protein-A affinity chromatography.
- 纯度
- > 95 % (by SDS-PAGE)
- 免疫原
- Human NK cell line LB2
- 克隆位点
- HP-MA4
- 亚型
- IgG2b kappa
-
anti-CD158a/g/h antibody (PE)
适用: 人 FACS 宿主: 小鼠 Monoclonal HP-MA4 PE
-
- 应用备注
- Flow cytometry: Recommended dilution: 1-4 μg/mL.
- 限制
- 仅限研究用
-
- 浓度
- 1 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store at 2-8°C. Do not freeze.
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-
: "Targeting natural killer cells to acute myeloid leukemia in vitro with a CD16 x 33 bispecific killer cell engager and ADAM17 inhibition." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 19, Issue 14, pp. 3844-55, (2013) (PubMed).
-
: "Targeting natural killer cells to acute myeloid leukemia in vitro with a CD16 x 33 bispecific killer cell engager and ADAM17 inhibition." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 19, Issue 14, pp. 3844-55, (2013) (PubMed).
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- 抗原
- CD158a/g/h
- 别名
- CD158agh
- 背景
- Killer cell immunoglobulin like receptor, two Ig d,Killer cell immunoglobulin-like receptors (KIRs) are polymorphic transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. They are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain (such as CD158a / KIR2DL1) transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain (such as CD158g / KIR2DS5, CD158h / KIR2DS1, or KIR2DS3) lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for CD158 isoforms are subsets of MHC class I molecules.,KIR2DL1, NKAT, KIR2DS1, KIR2DS3, NKAT7, KIR2DS5, NKAT9, CD158g, CD158h, CD158a
- 基因ID
- 3805
- UniProt
- Q99706
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