CD158a/g/h 抗体
There is 1 publication for this product available. The 小鼠 单克隆 anti-CD158a/g/h antibody is suitable to detect CD158a/g/h in samples from 人. It has been validated for FACS 和 IP.
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(1 reference)
产品编号 ABIN2749197
发货至:
中国
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Quick Overview for CD158a/g/h 抗体 (ABIN2749197)
抗原
CD158a/g/h
适用
人
宿主
小鼠
克隆类型
单克隆
标记
非结合性
应用范围
Flow Cytometry (FACS), Immunoprecipitation (IP)
克隆位点
HP-MA4
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原理
- Anti-Hu CD158agh Purified
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交叉反应 （详细）
- Human
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产品特性
- The mouse monoclonal antibody HP-MA4 recognizes an extracellular epitope of CD158 isoforms KIR2DL1 (CD158a), KIR2DS5 (CD158g), KIR2DS1 (CD158h), and KIR2DS3. It does not recognize the isoforms CD158b1,d,f,i,j.
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纯化方法
- Purified by protein-A affinity chromatography.
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纯度
- > 95 % (by SDS-PAGE)
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免疫原
- Human NK cell line LB2
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亚型
- IgG2b, kappa
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anti-CD158a/g/h antibody (PE)
适用: 人 FACS 宿主: 小鼠 Monoclonal HP-MA4 PE
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应用备注
- Flow cytometry: Recommended dilution: 1-4 μg/mL.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Do not freeze
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Do not freeze.
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: "Targeting natural killer cells to acute myeloid leukemia in vitro with a CD16 x 33 bispecific killer cell engager and ADAM17 inhibition." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 19, Issue 14, pp. 3844-55, (2013) (PubMed).
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: "Targeting natural killer cells to acute myeloid leukemia in vitro with a CD16 x 33 bispecific killer cell engager and ADAM17 inhibition." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 19, Issue 14, pp. 3844-55, (2013) (PubMed).
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- CD158a/g/h
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别名
- CD158agh
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背景
- Killer cell immunoglobulin like receptor, two Ig d,Killer cell immunoglobulin-like receptors (KIRs) are polymorphic transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. They are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain (such as CD158a / KIR2DL1) transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain (such as CD158g / KIR2DS5, CD158h / KIR2DS1, or KIR2DS3) lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for CD158 isoforms are subsets of MHC class I molecules.,KIR2DL1, NKAT, KIR2DS1, KIR2DS3, NKAT7, KIR2DS5, NKAT9, CD158g, CD158h, CD158a
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基因ID
- 3805
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UniProt
- Q99706
抗原
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