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- 抗原
- LARGE1
- 抗原表位
- AA 35-142
- 适用
- 人
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- PE
-
应用范围
- Flow Cytometry (FACS)
- 特异性
- The mouse monoclonal antibody LARGE-02 recognizes human LARGE1, a glycosyltransferase expressed mainly in the Golgi apparatus. Crossreactivity with LARGE2 was not determined.
- 交叉反应 （详细）
- Human
- 纯化方法
- Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- 免疫原
- Recombinant fragment of human LARGE1 (amino acids 35-142)
- 克隆位点
- LARGE-02
- 亚型
- IgG2b
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anti-LARGE1 (AA 35-142) antibody
适用: 人 FACS, WB 宿主: 小鼠 Monoclonal LARGE-02 unconjugated
anti-LARGE1 (AA 35-142) antibody (PE)适用: 人 FACS, WB 宿主: 小鼠 Monoclonal PE
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- 应用备注
- Flow cytometry: Recommended dilution: 1-5 μg/mL. Intracellular staining.
- 说明
-
The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate was purified by size-exclusion chromatography.
- 限制
- 仅限研究用
-
- 浓度
- 0.1 mg/mL
- 缓冲液
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
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- 抗原
- LARGE1
- 背景
- LARGE xylosyl- and glucuronyltransferase 1,LARGE1 serves as a glycosyltransferase which participates in glycosylation of the muscle membrane protein alpha-dystroglycan. Mutations of LARGE1 lead to hypoglycosylation of alpha-dystroglycan and cause congenital muscular dystrophy (MDC1D) associated with severe mental retardation. Altered alpha-dystroglycan glycosylation may also play a role in cancer, as hypoglycosylation of the protein and loss of laminin binding have been demonstrated in invasive carcinoma cells.,Xysosyl- and glucosyl transferase 1
- 基因ID
- 9215
- UniProt
- O95461
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