LARGE1 (AA 35-142) 抗体
This anti- antibody is a 小鼠 单克隆 antibody detecting in WB 和 FACS. Suitable for 人.
Quick Overview for LARGE1 (AA 35-142) 抗体 (ABIN2749093)
抗原
LARGE1
适用
人
宿主
小鼠
克隆类型
单克隆
标记
非结合性
应用范围
Western Blotting (WB), Flow Cytometry (FACS)
克隆位点
LARGE-02
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抗原表位
- AA 35-142
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原理
- Anti-LARGE1 Purified
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特异性
- The mouse monoclonal antibody LARGE-02 recognizes human LARGE1, a glycosyltransferase expressed mainly in the Golgi apparatus. Crossreactivity with LARGE2 was not determined.
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交叉反应 （详细）
- Human
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纯化方法
- Purified by protein-A affinity chromatography.
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纯度
- > 95 % (by SDS-PAGE)
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免疫原
- Recombinant fragment of human LARGE1 (amino acids 35-142)
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亚型
- IgG2b
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anti-LARGE1 (AA 35-142) antibody (PE)
适用: 人 ICFC 宿主: 小鼠 Monoclonal LARGE-02 PE
anti-LARGE1 (AA 35-142) antibody (PE)适用: 人 WB, FACS 宿主: 小鼠 Monoclonal PE
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应用备注
- Flow cytometry: Recommended dilution: 1-5 μg/mL. Intracellular staining.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Do not freeze.
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- LARGE1
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背景
- LARGE xylosyl- and glucuronyltransferase 1,LARGE1 serves as a glycosyltransferase which participates in glycosylation of the muscle membrane protein alpha-dystroglycan. Mutations of LARGE1 lead to hypoglycosylation of alpha-dystroglycan and cause congenital muscular dystrophy (MDC1D) associated with severe mental retardation. Altered alpha-dystroglycan glycosylation may also play a role in cancer, as hypoglycosylation of the protein and loss of laminin binding have been demonstrated in invasive carcinoma cells.,Xysosyl- and glucosyl transferase 1
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基因ID
- 9215
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UniProt
- O95461
抗原
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