CD79a 抗体 (AA 208-222)
(7 references)Quick Overview for CD79a 抗体 (AA 208-222) (ABIN2749074)
抗原
See all CD79a (CD79A) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 208-222
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原理
- Anti-Hu CD79a Purified
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特异性
- The mouse monoclonal antibody HM47 reacts with intracellular domain of CD79a (Ig alpha), a 40-45 kDa subunit of B cell antigen-specific receptor (BCR) and its early developmental forms.
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交叉反应 （详细）
- Human, Non-Human Primates, Porcine, Mouse, Rat, Bovine, Canine (Dog), Equine (Horse), Guinea pig, Rabbit, Chicken
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纯化方法
- Purified by protein-A affinity chromatography.
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纯度
- > 95 % (by SDS-PAGE)
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免疫原
- Synthetic peptide corresponding to C terminal amino acids 208-222 of human CD79a
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亚型
- IgG1 kappa
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anti-B-cell antigen receptor complex-associated protein alpha chain (CD79A) (AA 30-193) antibody
CD79A 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-B-cell antigen receptor complex-associated protein alpha chain (CD79A) (AA 202-216) antibodyCD79A 适用: 人, 小鼠, 大鼠, Cow, Pig, 猴 FACS, IF, WB, IHC, StM 宿主: 兔 Monoclonal IGA-1790R unconjugated Recombinant Antibody
anti-B-cell antigen receptor complex-associated protein alpha chain (CD79A) (AA 202-216) antibodyCD79A 适用: 人, 小鼠, 大鼠, Cow, Pig, 猴 FACS, IF, WB, IHC, StM 宿主: 小鼠 Monoclonal JCB117-HM47-A9 unconjugated
anti-B-cell antigen receptor complex-associated protein alpha chain (CD79A) (AA 33-145) antibodyCD79A 适用: 人 IF, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-B-cell antigen receptor complex-associated protein alpha chain (CD79A) antibodyCD79A 适用: 人 FACS, IF, IHC, StM 宿主: 小鼠 Monoclonal rIGA-764 unconjugated Recombinant Antibody
anti-B-cell antigen receptor complex-associated protein alpha chain (CD79A) (AA 202-216) antibody (FITC)CD79A 适用: 人, 小鼠, 大鼠, Cow, Pig, 小鸡, 兔, 马, 豚鼠, Opossum ICFC 宿主: 小鼠 Monoclonal HM57 FITC
anti-B-cell antigen receptor complex-associated protein alpha chain (CD79A) (AA 202-216) antibodyCD79A 适用: 人, 小鼠, 大鼠, Cow, Pig, 小鸡, 兔, 马, 豚鼠, Opossum FACS, IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal HM57 unconjugated
anti-B-cell antigen receptor complex-associated protein alpha chain (CD79A) (AA 208-222) antibody (PE)CD79A 适用: 人, 小鼠, 大鼠, Cow, Pig, 小鸡, 兔, 马, 豚鼠, 犬, Non-Human Primate ICFC 宿主: 小鼠 Monoclonal HM47 PE
anti-B-cell antigen receptor complex-associated protein alpha chain (CD79A) (AA 202-216) antibody (PE)CD79A 适用: 人, 小鼠, 大鼠, Cow, Pig, 小鸡, 兔, 马, 豚鼠, Opossum ICFC 宿主: 小鼠 Monoclonal HM57 PE
anti-B-cell antigen receptor complex-associated protein alpha chain (CD79A) (AA 70-142) antibodyCD79A 适用: 人 IF, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Flow cytometry: Recommended dilution: 1-4 μg/mL, intracellular staining.
Western blotting: Recommended dilution: 1-2 μg/mL. -
限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Do not freeze.
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: "C-MYC rearrangements are frequent in aggressive mature B-Cell lymphoma with atypical morphology." in: International journal of clinical and experimental pathology, Vol. 1, Issue 1, pp. 65-74, (2008) (PubMed).
: "CD79a is heterogeneously expressed in neoplastic and normal myeloid precursors and megakaryocytes in an antibody clone-dependent manner." in: American journal of clinical pathology, Vol. 128, Issue 2, pp. 306-13, (2007) (PubMed).
: "Immunohistochemical and histochemical stains for differentiating canine cutaneous round cell tumors." in: Veterinary pathology, Vol. 42, Issue 4, pp. 437-45, (2005) (PubMed).
: "Experimental infection of NOD/SCID mice reconstituted with human CD34+ cells with Epstein-Barr virus." in: Journal of virology, Vol. 78, Issue 24, pp. 13891-900, (2004) (PubMed).
: "B-cell markers in lymphocyte predominance Hodgkin disease." in: Archives of pathology & laboratory medicine, Vol. 126, Issue 7, pp. 862-3, (2002) (PubMed).
: "Expression of Ig-beta (CD79b) by chronic lymphocytic leukemia B cells that lack immunoglobulin heavy-chain allelic exclusion." in: Blood, Vol. 95, Issue 8, pp. 2725-7, (2000) (PubMed).
: "The IgM-associated protein mb-1 as a marker of normal and neoplastic B cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 147, Issue 11, pp. 2474-82, (1991) (PubMed).
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: "C-MYC rearrangements are frequent in aggressive mature B-Cell lymphoma with atypical morphology." in: International journal of clinical and experimental pathology, Vol. 1, Issue 1, pp. 65-74, (2008) (PubMed).
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- CD79a (CD79A) (B-cell antigen receptor complex-associated protein alpha chain (CD79A))
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别名
- CD79a
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背景
- CD79a molecule,CD79a (Ig alpha, MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.,BCR alpha, Ig-alpha, MB-1, IGA
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基因ID
- 973
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UniProt
- P11912
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途径
- BCR Signaling
抗原
-
