The mouse monoclonal antibody CARL-1 recognizes an extracellular epitope of CD255 / TWEAK, a type II transmembrane protein of the TNF superfamily able to induce apoptosis weakly in many cell types.
Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
4 °C
储存方法
Store at 2-8°C. Do not freeze.
Yoriki, Akashi, Sho, Nomi, Yamato, Hotta, Takayama, Matsumoto, Wakatsuki, Migita, Yagita, Nakajima: "Therapeutic potential of the TWEAK/Fn14 pathway in intractable gastrointestinal cancer." in: Experimental and therapeutic medicine, Vol. 2, Issue 1, pp. 103-108, (2012) (PubMed).
Brown, Ghosh, Winkles: "Full-length, membrane-anchored TWEAK can function as a juxtacrine signaling molecule and activate the NF-kappaB pathway." in: The Journal of biological chemistry, Vol. 285, Issue 23, pp. 17432-41, (2010) (PubMed).
Hosokawa, Hosokawa, Ozaki, Nakae, Matsuo: "Proinflammatory effects of tumour necrosis factor-like weak inducer of apoptosis (TWEAK) on human gingival fibroblasts." in: Clinical and experimental immunology, Vol. 146, Issue 3, pp. 540-9, (2006) (PubMed).
Saitoh, Nakayama, Nakano, Yagita, Yamamoto, Yamaoka: "TWEAK induces NF-kappaB2 p100 processing and long lasting NF-kappaB activation." in: The Journal of biological chemistry, Vol. 278, Issue 38, pp. 36005-12, (2003) (PubMed).
Nakayama, Kayagaki, Yamaguchi, Okumura, Yagita: "Involvement of TWEAK in interferon gamma-stimulated monocyte cytotoxicity." in: The Journal of experimental medicine, Vol. 192, Issue 9, pp. 1373-80, (2000) (PubMed).
抗原
CD255
别名
CD255 / TWEAK
背景
TNF superfamily member 12,CD255 / TWEAK (TNF-related weak inducer of apoptosis), a type II transmembrane protein expressed as membrane-bound and secreted form, can induce apoptosis in many tissues and cell lines through its receptor CD266 / TWEAK R. On the other hand, in endothelial cells this interaction can induce proliferation and promote angiogenesis including neovascularization of tumours. CD255 can act in a juxtacrine manner to initiate cellular responses, and induces secretion of pro-inflammatory cytokines. Besides CD266, CD255 may also bind to DR3.,TNFSF12, APO3L, DR3LG, TWEAK, TNLG4A