ARHGEF4 抗体 (AA 143-271)
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北京 101111
Quick Overview for ARHGEF4 抗体 (AA 143-271) (ABIN2749042)
抗原
See all ARHGEF4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 143-271
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原理
- Anti-ARHGEF4 Purified
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特异性
- The mouse monoclonal antibody ARHGEF-08 recognizes human intracellular protein ARHGEF4 / ASEF1, approx. 80 kDa guanine nucleotide exchange factor specific for Rac1 and Cdc42. The epitope is located in the rough at the region of SH3 domain.
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交叉反应 （详细）
- Human
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纯化方法
- Purified by protein-A affinity chromatography.
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纯度
- > 95 % (by SDS-PAGE)
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免疫原
- Recombinant fragment of human ARHGEF4 (amino acids 143-271)
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亚型
- IgG1
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anti-rho Guanine Nucleotide Exchange Factor (GEF) 4 (ARHGEF4) (N-Term) antibody
ARHGEF4 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-rho Guanine Nucleotide Exchange Factor (GEF) 4 (ARHGEF4) (N-Term) antibodyVerified ARHGEF4 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-rho Guanine Nucleotide Exchange Factor (GEF) 4 (ARHGEF4) (AA 143-271) antibody (PE)ARHGEF4 适用: 人 ICFC 宿主: 小鼠 Monoclonal ARHGEF-08 PE
anti-rho Guanine Nucleotide Exchange Factor (GEF) 4 (ARHGEF4) (AA 1-100) antibodyARHGEF4 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-rho Guanine Nucleotide Exchange Factor (GEF) 4 (ARHGEF4) (Internal Region) antibodyARHGEF4 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-rho Guanine Nucleotide Exchange Factor (GEF) 4 (ARHGEF4) (AA 51-100) antibodyARHGEF4 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Flow cytometry: Recommended dilution: 1-4 μg/mL. Intracellular staining.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Do not freeze.
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- ARHGEF4 (rho Guanine Nucleotide Exchange Factor (GEF) 4 (ARHGEF4))
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别名
- ARHGEF4
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背景
- Rho guanine nucleotide exchange factor 4,ARHGEF4 (Rho guanine nucleotide exchange factor 4), also known as ASEF 1 (adenomatous polyposis coli –, stimulated guanine nucleotide exchange factor 1) is an approximately 80 kDa cytoplasmic protein important for growth factor-mediated regulation of cell morphology and migration. Besides N-terminal adenomatous polyposis coli (APC)-binding region (ABR) it contains Dbl homology (DH), pleckstrin homology (PH) and SH3 domains. The SH3 domain inhibits GEF activity of ARHGEF4 by intramolecular interaction with the DH domain, whereas binding of APC stimulates the GEF activity. Activated ARHGEF4 stimulates the small GTPase Cdc42, which leads to decreased cell-cell adherence and enhanced cell migration.,ASEF1, GEF4, STM6
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基因ID
- 50649
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UniProt
- Q9NR80
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途径
- Neurotrophin Signaling Pathway
抗原
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