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- 抗原 See all PARP10 抗体
- PARP10 (Poly (ADP-Ribose) Polymerase Family, Member 10 (PARP10))
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抗原表位
- AA 1-907
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适用
- 人
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宿主
- 大鼠
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克隆类型
- 单克隆
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标记
- This PARP10 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)
- 特异性
- Recognizes human PARP-10 [ARTD10] with an epitope between aa 256-407, containing the glycine rich (G-rich) region.
- 交叉反应
- 人
- 免疫原
- Recombinant human PARP-10 [ARTD10] (aa 1-907) fused to a GST-tag.
- 克隆位点
- 5H11
- 亚型
- IgG1
- Top Product
- Discover our top product PARP10 Primary Antibody
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anti-Poly (ADP-Ribose) Polymerase Family, Member 10 (PARP10) antibody
PARP10 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Poly (ADP-Ribose) Polymerase Family, Member 10 (PARP10) (AA 565-597) antibodyPARP10 适用: 人 WB 宿主: 兔 Polyclonal RB56269 unconjugated
anti-Poly (ADP-Ribose) Polymerase Family, Member 10 (PARP10) antibodyPARP10 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Poly (ADP-Ribose) Polymerase Family, Member 10 (PARP10) (C-Term) antibodyPARP10 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Poly (ADP-Ribose) Polymerase Family, Member 10 (PARP10) (AA 251-300) antibodyPARP10 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Poly (ADP-Ribose) Polymerase Family, Member 10 (PARP10) (AA 1-300) antibodyPARP10 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Cell culture supernatant containing RPMI, 10 % FCS and 0.05 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: +4°C
Stable for at least 1 year after receipt when stored at +4°C. - 有效期
- 12 months
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- 抗原
- PARP10 (Poly (ADP-Ribose) Polymerase Family, Member 10 (PARP10))
- 别名
- PARP-10 [ARTD10] (PARP10 产品)
- 别名
- ARTD10 antibody, PARP10 antibody, poly(ADP-ribose) polymerase family member 10 antibody, poly (ADP-ribose) polymerase family, member 10 antibody, PARP10 antibody, Parp10 antibody
- 背景
- PARP-10 is a mono-ADP-ribosyltransferase and was initially identified as an interaction partner of the proto-oncoprotein Myc. PARP-10 possesses ubiquitin-interaction motifs, which are important to inhibit the activation of NF-kappaB and downstream target genes in response to interleukin-1beta and tumor necrosis factor-alpha. PARP-10 mono(ADP-ribosyl)ates (MARylates) NEMO (NF-kappaB essential modulator), which results in reduced NEMO polyubiquitylation and thus decreased NF-kappaB signaling. Overexpression of PARP-10 was shown to lead to apoptosis. PARP-10 knockdown leads to increased cell survival. Additional substrates of PARP-10, such as GSK-3beta were identified and PARP-10-mediated mono(ADP-ribosyl)ation (MARylation) was shown to be involved in regulating multiple processes, including Wnt signaling.
- UniProt
- Q53GL7
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