PARP10 抗体 (AA 1-907)
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北京 101111
Quick Overview for PARP10 抗体 (AA 1-907) (ABIN2745553)
抗原
See all PARP10 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-907
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原理
- anti-PARP-10 [ARTD10] (human), mAb (5H11)
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特异性
- Recognizes human PARP-10 [ARTD10] with an epitope between aa 256-407, containing the glycine rich (G-rich) region.
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产品特性
- Monoclonal Antibody. Recognizes human PARP-10 [ARTD10] with an epitope between aa 256-407, containing the glycine rich (G-rich) region. Isotype: Rat IgG1. Clone: 5H11. Applications: ICC, IP, WB. Liquid. Cell culture supernatant containing RPMI, 10 % FCS and 0.05 % sodium azide. PARP-10 is a mono-ADP-ribosyltransferase and was initially identified as an interaction partner of the proto-oncoprotein Myc. PARP-10 possesses ubiquitin-interaction motifs, which are important to inhibit the activation of NF-kappaB and downstream target genes in response to interleukin-1beta and tumor necrosis factor-alpha. PARP-10 mono(ADP-ribosyl)ates (MARylates) NEMO (NF-kappaB essential modulator), which results in reduced NEMO polyubiquitylation and thus decreased NF-kappaB signaling. Overexpression of PARP-10 was shown to lead to apoptosis. PARP-10 knockdown leads to increased cell survival. Additional substrates of PARP-10, such as GSK-3beta were identified and PARP-10-mediated mono(ADP-ribosyl)ation (MARylation) was shown to be involved in regulating multiple processes, including Wnt signaling.
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免疫原
- Recombinant human PARP-10 [ARTD10] (aa 1-907) fused to a GST-tag.
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亚型
- IgG1
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anti-Poly (ADP-Ribose) Polymerase Family, Member 10 (PARP10) antibody
PARP10 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Poly (ADP-Ribose) Polymerase Family, Member 10 (PARP10) (AA 300-350) antibodyPARP10 适用: 人, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Poly (ADP-Ribose) Polymerase Family, Member 10 (PARP10) (AA 565-597) antibodyPARP10 适用: 人 WB 宿主: 兔 Polyclonal RB56269 unconjugated
anti-Poly (ADP-Ribose) Polymerase Family, Member 10 (PARP10) antibodyPARP10 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Poly (ADP-Ribose) Polymerase Family, Member 10 (PARP10) (AA 251-300) antibodyPARP10 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Poly (ADP-Ribose) Polymerase Family, Member 10 (PARP10) (C-Term) antibodyPARP10 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Poly (ADP-Ribose) Polymerase Family, Member 10 (PARP10) (N-Term) antibodyPARP10 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Poly (ADP-Ribose) Polymerase Family, Member 10 (PARP10) (AA 1-300) antibodyPARP10 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Poly (ADP-Ribose) Polymerase Family, Member 10 (PARP10) (AA 300-350) antibodyPARP10 适用: 人 WB, IP, IHC (fp) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Cell culture supernatant containing RPMI, 10 % FCS and 0.05 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.
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储存条件
- 4 °C
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储存方法
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+4°C
+4°C
Stable for at least 1 year after receipt when stored at +4°C.
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有效期
- 12 months
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- PARP10 (Poly (ADP-Ribose) Polymerase Family, Member 10 (PARP10))
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别名
- PARP-10 [ARTD10]
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背景
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Alternate Names/Synonyms: ADP-ribosyltransferase Diphtheria Toxin-like 10, Poly(ADP-ribose) Polymerase-10
Product Description: PARP-10 [ARTD10] is a mono-ADP-ribosyltransferase and was initially identified as an interaction partner of the proto-oncoprotein Myc. PARP-10 possesses ubiquitin-interaction motifs, which are important to inhibit the activation of NF-kappaB and downstream target genes in response to interleukin-1beta [IL-1beta] and tumor necrosis factor-alpha [TNF-alpha]. PARP-10 mono(ADP-ribosyl)ates (MARylates) NEMO (NF-kappaB essential modulator), which results in reduced NEMO polyubiquitylation and thus decreased NF-kappaB signaling. Overexpression of PARP-10 was shown to lead to apoptosis. PARP-10 knockdown leads to increased cell survival. Additional substrates of PARP-10, such as GSK-3beta were identified and PARP-10-mediated mono(ADP-ribosyl)ation (MARylation) was shown to be involved in regulating multiple processes, including Wnt signaling.
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UniProt
- Q53GL7
抗原
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