LPP 抗体 (AA 1-109)
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北京 101111
Quick Overview for LPP 抗体 (AA 1-109) (ABIN2745541)
抗原
See all LPP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-109
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特异性
- Recognizes human, rat and pig LPP.
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交叉反应
- 人, 猪, 大鼠
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纯化方法
- Antigen affinity purified.
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组件
- Contains Positive Control: Human skin fibroblast protein, supplied at 1mg/ml in SDS (Laemmli) sample buffer. Use 25μl (25μg) per lane for Western blotting.
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免疫原
- Recombinant human lipoma preferred partner (LPP) (aa 1-109).
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应用备注
- Use 25 μL (25 μg) per lane for Western blotting.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- In PBS containing 0.01 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. -
有效期
- 12 months
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- LPP (Lipoma-preferred partner (LPP))
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别名
- Lipoma Preferred Partner
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背景
- Lipoma preferred partner (LPP) is encoded by the preferred fusion partner gene of the high mobility group protein HMGI-C. LPP is frequently affected by chromosomal translocations in a major group of soft tissue lipomas, as well as in a parosteal lipoma and in pulmonary chondroid hamartomas. The resulting fusion proteins comprise three DNA binding domains of HMGI-C fused to two or three C-terminal LIM domains of LPP and a reciprocal product, respectively. Expression of a HMGI-C/LPP fusion protein causes malignant transformation of fibroblasts. Similar to its relatives zyxin and TRIP (thyroid receptor interacting protein 6) / ZRP-1 (zyxin-related protein 1), LPP consists of a N-terminal proline-rich domain followed by three C-terminal LIM domains (double zinc finger structures that are involved in protein-protein interactions). Like the cytoskeletal protein zyxin, LPP localizes to focal adhesions and cell-cell adherens junctions. LPP harbors a nuclear export signal and displays transcriptional activation capacity.
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UniProt
- Q93052
抗原
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