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LPP 抗体 (AA 1-109)

The 兔 多克隆 anti-LPP antibody (ABIN2745541) specifically detects LPP in WB, ICC 和 IP. The antibody is reactive with 人, 大鼠 和 Pig samples.
产品编号 ABIN2745541
发货至: 中国
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Quick Overview for LPP 抗体 (AA 1-109) (ABIN2745541)

抗原

See all LPP 抗体
LPP (Lipoma-preferred partner (LPP))

适用

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人, 大鼠, Pig

宿主

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克隆类型

  • 44
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多克隆

标记

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This LPP antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunocytochemistry (ICC), Immunoprecipitation (IP)
  • 抗原表位

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    AA 1-109

    特异性

    Recognizes human, rat and pig LPP.

    交叉反应

    人, 猪, 大鼠

    纯化方法

    Antigen affinity purified.

    组件

    Contains Positive Control: Human skin fibroblast protein, supplied at 1mg/ml in SDS (Laemmli) sample buffer. Use 25μl (25μg) per lane for Western blotting.

    免疫原

    Recombinant human lipoma preferred partner (LPP) (aa 1-109).
  • 应用备注

    Use 25 μL (25 μg) per lane for Western blotting.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    Lot specific

    缓冲液

    In PBS containing 0.01 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 1 year after receipt when stored at -20°C.

    有效期

    12 months
  • 抗原

    LPP (Lipoma-preferred partner (LPP))

    别名

    Lipoma Preferred Partner

    背景

    Lipoma preferred partner (LPP) is encoded by the preferred fusion partner gene of the high mobility group protein HMGI-C. LPP is frequently affected by chromosomal translocations in a major group of soft tissue lipomas, as well as in a parosteal lipoma and in pulmonary chondroid hamartomas. The resulting fusion proteins comprise three DNA binding domains of HMGI-C fused to two or three C-terminal LIM domains of LPP and a reciprocal product, respectively. Expression of a HMGI-C/LPP fusion protein causes malignant transformation of fibroblasts. Similar to its relatives zyxin and TRIP (thyroid receptor interacting protein 6) / ZRP-1 (zyxin-related protein 1), LPP consists of a N-terminal proline-rich domain followed by three C-terminal LIM domains (double zinc finger structures that are involved in protein-protein interactions). Like the cytoskeletal protein zyxin, LPP localizes to focal adhesions and cell-cell adherens junctions. LPP harbors a nuclear export signal and displays transcriptional activation capacity.

    UniProt

    Q93052
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