alpha Tubulin 抗体
Quick Overview for alpha Tubulin 抗体 (ABIN2745507)
抗原
See all alpha Tubulin (TUBA1) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
特异性
- Detects K40 acetylation of alpha-tubulin, signal specifically increased by modification with tubulin acetyl transferase alpha-TAT1.
-
交叉反应
- 所有种类
-
纯度
- >95 % (SDS-PAGE)
-
免疫原
- Tubulin of the Ciliate Euplotes eluted from the 55kDa band of SDS gel.
-
亚型
- IgG1
-
-
anti-alpha Tubulin (TUBA1) antibody
TUBA1 适用: 人, 小鼠, Pig, Saccharomyces cerevisiae, Arabidopsis, Nicotiana tabacum, Eisenia fetida, Turkey, Paramecium WB, IHC (p), IP, ICC, ICFC 宿主: 小鼠 Monoclonal TU-01 unconjugated
anti-alpha Tubulin (TUBA1) antibody (FITC)TUBA1 适用: 人, 小鼠, Pig, Saccharomyces cerevisiae, Arabidopsis, Nicotiana tabacum, Eisenia fetida, Turkey, Paramecium ICC, FACS 宿主: 小鼠 Monoclonal TU-01 FITC
anti-alpha Tubulin (TUBA1) antibody (Biotin)TUBA1 适用: 人, 小鼠, Pig, Saccharomyces cerevisiae, Arabidopsis, Nicotiana tabacum, Eisenia fetida, Turkey, Paramecium WB, IHC (p), ICC, ICFC 宿主: 小鼠 Monoclonal TU-01 Biotin
anti-alpha Tubulin (TUBA1) antibodyTUBA1 适用: 人, 小鼠, 大鼠, Pig, 犬, Nicotiana tabacum WB, ELISA, IHC (p), IP, ICC 宿主: 小鼠 Monoclonal TU-16 unconjugated
anti-alpha Tubulin (TUBA1) (acLys40) antibodyTUBA1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-alpha Tubulin (TUBA1) antibodyTUBA1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-alpha Tubulin (TUBA1) antibodyTUBA1 适用: 人, 小鼠, 大鼠, Pig, Cow, Saccharomyces cerevisiae, 猴, 犬, Hamster, 豚鼠, Sea Urchin, Amphibian, 山羊, Kangaroo WB, IHC, IHC (p), IP 宿主: 小鼠 Monoclonal DM1A unconjugated
anti-alpha Tubulin (TUBA1) (Subunit alpha) antibodyTUBA1 适用: 人, Saccharomyces cerevisiae, 哺乳动物, Avian, Drosophila melanogaster, Fungus WB, ELISA, IHC, IHC (p), IHC (fro), RIA 宿主: 大鼠 Monoclonal YOL1-34 unconjugated
anti-alpha Tubulin (TUBA1) antibodyTUBA1 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-alpha Tubulin (TUBA1) (AA 419-435) antibodyTUBA1 适用: 人, 小鼠, 大鼠, Saccharomyces cerevisiae, Vertebrate, Invertebrate WB, ELISA, IP, ICC 宿主: 小鼠 Monoclonal 3A2 unconjugated
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- Lot specific
-
缓冲液
- In PBS containing 10 % glycerol and 0.02 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. -
有效期
- 12 months
-
-
- alpha Tubulin (TUBA1)
-
别名
- alpha-Tubulin
-
背景
- Microtubules are key elements of the eukaryotic cytoskeleton that dynamically assemble from heterodimers of alpha- and beta-tubulin. Two different mechanisms can generate microtubule diversity: the expression of different alpha- and beta-tubulin genes, referred to as tubulin isotypes, and the generation of posttranslational modifications (PTMs) on alpha- and beta-tubulin. Tubulin PTMs include the well-known acetylation or phosphorylation, and others that have so far mostly been found on tubulin, detyrosination/tyrosination, polyglutamylation and polyglycylation. These PTMs might have evolved to specifically regulate tubulin and microtubule functions. Tubulin acetylation was discovered on K40 of flagellar alpha-tubulin in Chlamydomonas reinhardtii and is generally enriched on stable microtubules in cells. It is located on the microtubule lumenal surface. As a result of its localization at the inner face of microtubules, K40 acetylation might rather affect the binding of microtubule inner proteins, a poorly characterized family of proteins. Functional experiments in cells have further suggested that K40 acetylation regulates intracellular transport by regulating the traffic of kinesin motors probably by indirect mechanisms. Acetyltransferase alpha-Tat1 (or Mec-17) specifically acetylate alpha-tubulin K40. Acetylation of tubulin by alpha-Tat1 accumulates selectively in stable, long-lived microtubules thus explaining the link between this posttranslational modication and stable microtubules in cells. However, the direct cellular function of K40 acetylation on microtubules is still unclear.
-
途径
- Microtubule Dynamics
抗原
-
