PDE10A 抗体
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- 抗原 See all PDE10A 抗体
- PDE10A (phosphodiesterase 10A (PDE10A))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This PDE10A antibody is un-conjugated
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应用范围
- Western Blotting (WB), Flow Cytometry (FACS)
- 产品特性
- Homo sapiens phosphodiesterase 10A (PDE10A), transcript variant 2
- 纯化方法
- Purified from mouse ascites fluids by affinity chromatography
- 免疫原
- Full length human recombinant protein of human PDE10A (NP_006652) produced in HEK293T cell.
- 克隆位点
- 4A10
- 亚型
- IgG1
- Top Product
- Discover our top product PDE10A Primary Antibody
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- 应用备注
- WB:1:500, FC:1:50
- 说明
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The concentration of the product may vary between diferrent lots.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.5-1.0 mg/mL
- 缓冲液
- PBS ( pH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
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- 抗原
- PDE10A (phosphodiesterase 10A (PDE10A))
- 别名
- PDE10A (PDE10A 产品)
- 别名
- HSPDE10A antibody, Pde10a3 antibody, phosphodiesterase 10A antibody, PDE10A antibody, Pde10a antibody
- 背景
- Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3'cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. There are 11 subtypes of PDEs, named PDE1-11, PDE4, 7 and 8 selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both cyclic nucleotides. PDEs are expressed ubiquitously,with each subtype having a specific tissue distribution. These enzymes are involved in many signal transduction pathways and their functions include vascular smooth muscle proliferation and contraction, cardiac contractility,platelet aggregation, hormone secretion, immune cell activation, and they are involved in learning and memory.
- 分子量
- 88.4 kDa
- 基因ID
- 10846
- NCBI登录号
- NM_006661
- HGNC
- 10846
- 途径
- cAMP Metabolic Process
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