ACTN3 抗体
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Quick Overview for ACTN3 抗体 (ABIN272284)
抗原
See all ACTN3 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of Actinin-α3 protein. (region surrounding Glu25)
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交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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纯度
- > 95 % pure by SDS-PAGE
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anti-Actinin, alpha 3 (ACTN3) (N-Term) antibody
ACTN3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Actinin, alpha 3 (ACTN3) (Center) antibodyACTN3 适用: 人, 小鼠, 大鼠 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Actinin, alpha 3 (ACTN3) antibodyACTN3 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Actinin, alpha 3 (ACTN3) (AA 580-630) antibodyACTN3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Actinin, alpha 3 (ACTN3) (AA 574-617), (C-Term) antibodyACTN3 适用: 人, 小鼠, 大鼠 WB, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Actinin, alpha 3 (ACTN3) (N-Term) antibodyACTN3 适用: 人, 小鼠, 大鼠, Cow, 兔, 犬, 豚鼠, 马, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Actinin, alpha 3 (ACTN3) (N-Term) antibodyACTN3 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Actinin, alpha 3 (ACTN3) (AA 162-416) antibodyACTN3 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Actinin, alpha 3 (ACTN3) (AA 180-229) antibodyACTN3 适用: 人, 小鼠, 大鼠, Cow, 兔, 犬, 豚鼠, 马, Hamster, 猴, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Actinin, alpha 3 (ACTN3) (AA 409-437) antibodyACTN3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB31768 unconjugated
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应用备注
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ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1,0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- DO NOT FREEZE!
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- ACTN3 (Actinin, alpha 3 (ACTN3))
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别名
- alpha-Actinin-3 / ACTN3
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背景
- The spectrin gene family encodes a diverse group of cytoskeletal proteins that include spectrins, dystrophins and α-actinins. There are four tissue-specific α-actinins, namely α-actinin-1, α-actinin-2, α-actinin-3 and α-actinin-4, which are localized to muscle and non-muscle cells, including skeletal, cardiac and smooth muscle cells, as well as within the cytoskeleton. Each α-actinin protein contains one Actin-binding domain, two calponin-homology domains, two EF-hand domains and four spectrin repeats, through which they function as bundling proteins that can cross-link F-Actin, thus anchoring Actin to a variety of intracellular structures. Defects in the gene encoding α-actinin-4 are the cause of focal segmental glomerulosclerosis 1 (FSGS1), a common renal lesion characterized by decreasing kidney function and, ultimately, renal failure.Synonyms: Alpha actinin skeletal muscle isoform 3, F-actin cross-linking protein
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分子量
- approx. 103 kDa
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基因ID
- 89
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NCBI登录号
- NP_001095
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UniProt
- Q08043
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途径
- Cell-Cell Junction Organization
抗原
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