IB2 抗体
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北京 101111
Quick Overview for IB2 抗体 (ABIN272223)
抗原
See all IB2 (JIP-2) 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of JIP-2 protein. (region surrounding asn601)
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交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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纯度
- > 95 % pure by SDS-PAGE
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anti-C-Jun-Amino-Terminal Kinase-Interacting Protein 2 (JIP-2) antibody
JIP-2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-C-Jun-Amino-Terminal Kinase-Interacting Protein 2 (JIP-2) (AA 579-774) antibodyJIP-2 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-C-Jun-Amino-Terminal Kinase-Interacting Protein 2 (JIP-2) (AA 581-630) antibodyJIP-2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-C-Jun-Amino-Terminal Kinase-Interacting Protein 2 (JIP-2) (C-Term) antibodyJIP-2 适用: 人, 小鼠, 大鼠, 斑马鱼 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-C-Jun-Amino-Terminal Kinase-Interacting Protein 2 (JIP-2) (AA 470-570) antibodyJIP-2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-C-Jun-Amino-Terminal Kinase-Interacting Protein 2 (JIP-2) (AA 307-356) antibodyJIP-2 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1: 5000approx. 1: 10000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1,0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.2., 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- DO NOT FREEZE!
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- IB2 (JIP-2) (C-Jun-Amino-Terminal Kinase-Interacting Protein 2 (JIP-2))
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别名
- JIP-2
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背景
- C-Jun NH2-terminal kinases (JNKs) are distant members of the MAP kinase family. JNK1 is activated by dual phosphorylation at a Thr-Pro-Tyr motif in response to ultraviolet (UV) light, and it functions to phosphorylate c-Jun at amino terminal serine regulatory sites, Ser 63 and Ser 73, resulting in transcriptional activation. Two additional JNK family members have been identified as JNK2 and JNK3. JIP-1 (for JNK interacting protein-1) has been identified as a cytoplasmic inhibitor of JNK that retains JNK in the cytoplasm, thereby inhibiting JNK-regulated gene expression. Evidence suggests that JNK1 and JNK2 bind to JIP-1 with greater affinity than to ATF-2 and c-Jun, which are targets of the JNK signaling pathway. JIP-1 contains an amino terminal JNK binding domain and a carboxy terminal SH3 domain. ATF-2 and c-Jun also contain the JNK binding domain and are thought to compete with JIP-1 for JNK binding. Multiple splice variants of JIP-1, including JIP-1b, JIP-1c (also designated islet-brain 1 or IB-1), JIP-2a, JIP-2b and JIP-3, have been identified in brain.Synonyms: C-jun-amino-terminal kinase-interacting protein 2, IB2, Islet-brain-2, JIP2, JNK MAP kinase scaffold protein 2, JNK-interacting protein 2, MAPK8IP2, Mitogen-activated protein kinase 8-interacting protein 2, PRKM8IPL
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分子量
- approx. 88 kDa
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基因ID
- 23542
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NCBI登录号
- NP_036456
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UniProt
- Q13387
抗原
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