CDK5R2 抗体
Quick Overview for CDK5R2 抗体 (ABIN272221)
抗原
See all CDK5R2 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of p39 protein. (region surrounding asn100)
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交叉反应 （详细）
- Species reactivity (tested):Human.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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纯度
- > 95 % pure by SDS-PAGE
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anti-Cyclin-Dependent Kinase 5, Regulatory Subunit 2 (p39) (CDK5R2) (Internal Region) antibody
CDK5R2 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 5, Regulatory Subunit 2 (p39) (CDK5R2) (Internal Region) antibodyCDK5R2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 5, Regulatory Subunit 2 (p39) (CDK5R2) (AA 1-367) antibodyCDK5R2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 5, Regulatory Subunit 2 (p39) (CDK5R2) antibodyCDK5R2 适用: 人 WB 宿主: 兔 Monoclonal 25GB1865 unconjugated Recombinant Antibody
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应用备注
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ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1,0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- DO NOT FREEZE!
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- CDK5R2 (Cyclin-Dependent Kinase 5, Regulatory Subunit 2 (p39) (CDK5R2))
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别名
- CDK5R2
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背景
- Cyclin dependent kinases, known as Cdks, regulate transitions in the eukaryotic cell cycle. Cdk 5 is required for proper development of the mammalian central nervous system and is predominantly expressed in neurons. Neuronal Cdk5 can be activated by two accessory proteins designated p35nck5a and p39nck5ai, which is also known as p39. The human p39 gene maps to chromosome 2q35 and encodes a 367-amino acid, 39 kDa protein. p35 and p39 both share limited similarity to cyclins and may define a distinct family of cyclin-dependent kinase activating proteins. During embryonic rat brain development, the expression pattern of p39 appears to have an inverse relationship to that of Cdk5 and p35, suggesting that these proteins may have region-specific and developmental stage-specific functions in rat brain. p39 can localize to lamellipodial and fillopodial structures of cells and in growth cones of neurons. In addition, p39 can colocalize with actin, suggesting that p39 plays a role in regulating actin cytoskeletal dynamics in cells. The temporal and spatial expression of p39 in synaptic junctions indicates a possible role of the p39/cdk5 kinase at the synapse.Synonyms: CDK5 activator 2, Cyclin-dependent kinase 5 activator 2, Cyclin-dependent kinase 5 regulatory subunit 2, NCK5AI, P39, P39I
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分子量
- approx. 40 kDa
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基因ID
- 8941
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NCBI登录号
- NP_003927
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UniProt
- Q13319
抗原
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