HNF1A 抗体
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北京 101111
Quick Overview for HNF1A 抗体 (ABIN272184)
抗原
See all HNF1A 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of TCF-1 protein. (region surrounding Phe26)
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交叉反应 （详细）
- Species reactivity (tested):Human, Mouse.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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纯度
- > 95 % pure by SDS-PAGE
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anti-HNF1 Homeobox A (HNF1A) antibody
HNF1A 适用: 人 WB, IP, IHC (p), ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-HNF1 Homeobox A (HNF1A) (AA 214-339) antibodyHNF1A 适用: 人 IHC, ELISA 宿主: 小鼠 Monoclonal HNF1A-2087 unconjugated
anti-HNF1 Homeobox A (HNF1A) (AA 532-631) antibodyHNF1A 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6G4 unconjugated
anti-HNF1 Homeobox A (HNF1A) (AA 179-228) antibodyHNF1A 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, Pig, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-HNF1 Homeobox A (HNF1A) (N-Term) antibodyHNF1A 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, Cow WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-HNF1 Homeobox A (HNF1A) (Internal Region) antibodyVerified HNF1A 适用: 人 ELISA, FACS, IF 宿主: 山羊 Polyclonal unconjugated
anti-HNF1 Homeobox A (HNF1A) (N-Term) antibodyHNF1A 适用: 人, 小鼠, 大鼠, Pig, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-HNF1 Homeobox A (HNF1A) (AA 431-631) antibodyHNF1A 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-HNF1 Homeobox A (HNF1A) (AA 177-205) antibodyHNF1A 适用: 人, 小鼠 WB, IF 宿主: 兔 Polyclonal RB22893 unconjugated
anti-HNF1 Homeobox A (HNF1A) (AA 177-205) antibodyHNF1A 适用: 人, 小鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1,0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- DO NOT FREEZE!
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- HNF1A (HNF1 Homeobox A (HNF1A))
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别名
- HNF1 alpha / TCF1
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背景
- T-cell factor-1 (TCF-1) is a DNA-binding transcriptional activator that isessential for lymphoid cell development. The TCF family of transcription factors are activated by the Wnt-1 and Wingless pathways and are characterized by the presence of a conserved protein motif, the high mobility group (HMG) 1 box, which mediates DNA binding. Several alternative splice variants of TCF-1 have been identified, including TCF-1A, which share a conserved amino terminus and differ in the carboxy terminal sequences. The Wnt mediated signaling pathway induces cytosolic β-catenin binding to TCF proteins within the nucleus, leading to the enhanced expression of the Wnt target genes. The β-catenin-TCF complexes are negatively regulated by the adenomatous polyposis coli (APC) tumor suppressor protein, which phosphorylates β-catenin and, in turn, increases the degradation of cytosolic β-catenin and inhibits the transcriptional activity of the TCF proteins. Mutations in the APC gene, which are commonly observed in colorectal carcinomas, disrupt this regulatory pathway and correlate with an accumulation of β-catenin and the increased activation of the TCF target genes.Synonyms: HNF1A, Hepatocyte nuclear factor 1-alpha, LF-B1, LFB1, Liver-specific transcription factor LF-B1, TCF-1, Transcription factor 1
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分子量
- approx. 42 kDa
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基因ID
- 6927
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NCBI登录号
- NP_000536
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UniProt
- P20823
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途径
- Hormone Transport, Carbohydrate Homeostasis
抗原
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