PAR1 抗体
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- 抗原 See all PAR1 (F2R) 抗体
- PAR1 (F2R) (Coagulation Factor II (thrombin) Receptor (F2R))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PAR1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 特异性
- This antibody detects endogenous levels of PAR1 protein. (region surrounding Gly17)
- 交叉反应 （详细）
- Species reactivity (tested):Human.
- 纯化方法
- Affinity Chromatography using epitope-specific immunogen.
- Top Product
- Discover our top product F2R Primary Antibody
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anti-Coagulation Factor II (thrombin) Receptor (F2R) (AA 251-350) antibody
F2R 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor II (thrombin) Receptor (F2R) (AA 42-102) antibodyF2R 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 2C5 unconjugated
anti-Coagulation Factor II (thrombin) Receptor (F2R) (N-Term) antibodyF2R 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor II (thrombin) Receptor (F2R) (AA 42-176) antibodyF2R 适用: 人 WB, ELISA, IHC, FACS, ICC, Neut 宿主: 小鼠 Monoclonal 5E2E6 unconjugated
anti-Coagulation Factor II (thrombin) Receptor (F2R) (AA 61-76), (Extracellular), (N-Term) antibodyF2R 适用: 人 WB, IHC, FACS, ICC, IF, LCI 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor II (thrombin) Receptor (F2R) (AA 42-102) antibodyF2R 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor II (thrombin) Receptor (F2R) antibodyF2R 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Coagulation Factor II (thrombin) Receptor (F2R) (AA 1-425) antibodyF2R 适用: 人 WB, FACS 宿主: 小鼠 Polyclonal unconjugated
anti-Coagulation Factor II (thrombin) Receptor (F2R) (Internal Region) antibodyVerified F2R 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Coagulation Factor II (thrombin) Receptor (F2R) (AA 267-316) antibodyF2R 适用: 人, 大鼠, 小鼠, Pig, 兔 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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ELISA: 1/10000approx. 1/20000. Western blot: 1/500approx. 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS), pH 7.2, 0.05 % Sodium Azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in alqiuots) at -20 °C for longer.
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- 抗原
- PAR1 (F2R) (Coagulation Factor II (thrombin) Receptor (F2R))
- 别名
- Thrombin Receptor / F2R (F2R 产品)
- 别名
- CF2R antibody, HTR antibody, PAR-1 antibody, PAR1 antibody, TR antibody, Par1 antibody, TRGPC antibody, AI482343 antibody, Cf2r antibody, ThrR antibody, Par-1 antibody, f2r-a antibody, par1 antibody, coagulation factor II thrombin receptor antibody, coagulation factor II (thrombin) receptor antibody, coagulation factor 2 (thrombin) receptor L homeolog antibody, F2R antibody, F2r antibody, f2r.L antibody
- 背景
- Thrombin receptor (also designated protease-activated receptor-1 or PAR-1), PAR-2 and PAR-3 compose a distinct class of G protein-coupled receptors activated by proteolysis. Cleavage of these receptors by proteases occurs within the amino-terminal extracellular domain. Thrombin, a serine protease involved in platelet aggregation and blood coagulation, activates the thrombin receptor, resulting in elevated intracellular calcium levels in platelets. Thrombin also cleaves PAR-3 in vitro, suggesting that PAR-3 may be involved in thrombosis or mitogenesis. Thrombin receptor and PAR-4 appear to account for most thrombin signaling in platelets. Activation of PAR-2 in vitro is induced by trypsin, suggesting that PAR-2 is not an alternative thrombin receptor. Cytokines including TNF-alpha and IL-1beta increase PAR-2 expression, indicating PAR-2 involvement in the acute inflammatory response.Synonyms: CF2R, Coagulation factor II receptor, PAR-1, PAR1, Proteinase-activated receptor 1
- 分子量
- approx. 48 kDa
- 基因ID
- 2149
- NCBI登录号
- NP_001983
- UniProt
- P25116
- 途径
- Nuclear Receptor Transcription Pathway, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus
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