RPH3A 抗体
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北京 101111
Quick Overview for RPH3A 抗体 (ABIN272075)
抗原
See all RPH3A 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of Rabphilin 3A protein. (region surrounding Pro231)
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交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
纯化方法
- Affinity Chromatography using epitope-specific immunogen
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anti-Rabphilin 3A (RPH3A) (AA 203-252), (pSer237) antibody
RPH3A 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Rabphilin 3A (RPH3A) (Center) antibodyRPH3A 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Rabphilin 3A (RPH3A) (N-Term) antibodyRPH3A 适用: 人, 小鼠, 大鼠, 犬, Cow, 小鸡, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Rabphilin 3A (RPH3A) (AA 1-280) antibodyRPH3A 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Rabphilin 3A (RPH3A) (Tyr627) antibodyRPH3A 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Rabphilin 3A (RPH3A) (AA 151-200) antibodyRPH3A 适用: 人, 小鼠, 大鼠, 犬, 马, 兔, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Rabphilin 3A (RPH3A) (AA 35-84) antibodyRPH3A 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 兔, 豚鼠, 猴, Bat, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Rabphilin 3A (RPH3A) (pSer234) antibodyRPH3A 适用: 小鼠, 大鼠 WB, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Rabphilin 3A (RPH3A) (AA 671-684) antibodyRPH3A 适用: 人, 小鼠, 大鼠, Cow WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1: 1000approx. 1: 5000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200. IF: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- RPH3A (Rabphilin 3A (RPH3A))
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别名
- Rabphilin-3A / RPH3A
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背景
- The carboxy-terminal of rabphilin-3A consists of two C2 domains, A and B,and the amino-terminal (residues 45-170) contains a cysteine-rich rich region with two zinc finger motifs. Rabphilin-3A belongs to a family of other carboxyterminal type (C-type) tandem C2 proteins, which includes synaptotagmins and Doc2. Rabphilin is expressed in neuroendocrine cells and co-localizes with Rab3A on synaptic vesicles and chromaffin granules. Rabphilin-3A binds Rab3a/GTP/Mg+ within amino-terminal residues 45 and 170. Rabphilin-3A binds calcium ions and phosphatidylinositol 4,5-bisphophate containing lipid vesicles within its C2 domains. Rabphilin-3A is a positive regulator of calcium dependent exocytosis, while Rab3a is a negative regulator of exocytosis. Although rabphilin-3A associates with Rab3a, they seem to influence exocytosis independently of each other. Rabphilin-3A effects are likely mediated through interactions with an unknown factor that recognizes the Rab3 binding domain.Synonyms: Exophilin 1, Exophilin-1, KIAA0985, Rabphilin 3A
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分子量
- approx. 75 kDa
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基因ID
- 22895
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NCBI登录号
- NP_001137326
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UniProt
- Q9Y2J0
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途径
- Synaptic Vesicle Exocytosis
抗原
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