RPH3A 抗体
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- 抗原 See all RPH3A 抗体
- RPH3A (Rabphilin 3A (RPH3A))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This RPH3A antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 特异性
- This antibody detects endogenous levels of Rabphilin 3A protein. (region surrounding Pro231)
- 交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. - 纯化方法
- Affinity Chromatography using epitope-specific immunogen
- Top Product
- Discover our top product RPH3A Primary Antibody
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anti-Rabphilin 3A (RPH3A) (AA 1-280) antibody
RPH3A 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Rabphilin 3A (RPH3A) (pSer234) antibodyRPH3A 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Rabphilin 3A (RPH3A) antibodyRPH3A 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Rabphilin 3A (RPH3A) (pSer234) antibodyRPH3A 适用: 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Rabphilin 3A (RPH3A) (C-Term) antibodyRPH3A 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Rabphilin 3A (RPH3A) antibodyRPH3A 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Rabphilin 3A (RPH3A) (AA 203-252), (pSer237) antibodyRPH3A 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Rabphilin 3A (RPH3A) antibodyRPH3A 适用: 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Rabphilin 3A (RPH3A) (AA 1-280) antibodyRPH3A 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Rabphilin 3A (RPH3A) (Tyr627) antibodyRPH3A 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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ELISA: 1: 1000approx. 1: 5000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200. IF: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- 抗原
- RPH3A (Rabphilin 3A (RPH3A))
- 别名
- Rabphilin-3A / RPH3A (RPH3A 产品)
- 别名
- 2900002P20Rik antibody, AU022689 antibody, AW108370 antibody, CG11556 antibody, Dmel\\CG11556 antibody, exophilin-1 antibody, fc61h10 antibody, rph3a antibody, wu:fc61h10 antibody, rabphilin 3A antibody, Rabphilin antibody, rabphilin-3a, putative antibody, rabphilin-3A antibody, rabphilin 3A S homeolog antibody, rabphilin 3A homolog (mouse), a antibody, RPH3A antibody, Rph3a antibody, Rph antibody, Smp_145120 antibody, Tsp_00335 antibody, rph3a.S antibody, rph3aa antibody
- 背景
- The carboxy-terminal of rabphilin-3A consists of two C2 domains, A and B,and the amino-terminal (residues 45-170) contains a cysteine-rich rich region with two zinc finger motifs. Rabphilin-3A belongs to a family of other carboxyterminal type (C-type) tandem C2 proteins, which includes synaptotagmins and Doc2. Rabphilin is expressed in neuroendocrine cells and co-localizes with Rab3A on synaptic vesicles and chromaffin granules. Rabphilin-3A binds Rab3a/GTP/Mg+ within amino-terminal residues 45 and 170. Rabphilin-3A binds calcium ions and phosphatidylinositol 4,5-bisphophate containing lipid vesicles within its C2 domains. Rabphilin-3A is a positive regulator of calcium dependent exocytosis, while Rab3a is a negative regulator of exocytosis. Although rabphilin-3A associates with Rab3a, they seem to influence exocytosis independently of each other. Rabphilin-3A effects are likely mediated through interactions with an unknown factor that recognizes the Rab3 binding domain.Synonyms: Exophilin 1, Exophilin-1, KIAA0985, Rabphilin 3A
- 分子量
- approx. 75 kDa
- 基因ID
- 22895
- NCBI登录号
- NP_001137326
- UniProt
- Q9Y2J0
- 途径
- Synaptic Vesicle Exocytosis
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