PKC mu 抗体
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Quick Overview for PKC mu 抗体 (ABIN272066)
抗原
See all PKC mu (PRKD1) 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels ofPKD1/PKC mu protein. (region surrounding Gly459)
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交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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纯度
- > 95 % pure by SDS-PAGE
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anti-Protein Kinase D1 (PRKD1) antibody
PRKD1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase D1 (PRKD1) (pTyr463) antibodyPRKD1 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase D1 (PRKD1) antibodyPRKD1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB4590 unconjugated Recombinant Antibody
anti-Protein Kinase D1 (PRKD1) (pSer910) antibodyPRKD1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase D1 (PRKD1) (AA 383-395) antibodyVerified PRKD1 适用: 人 WB, ELISA, IP 宿主: 山羊 Polyclonal unconjugated
anti-Protein Kinase D1 (PRKD1) (AA 233-246) antibodyVerified PRKD1 适用: 人 WB, ELISA, IHC, IP 宿主: 山羊 Polyclonal unconjugated
anti-Protein Kinase D1 (PRKD1) (AA 314-404) antibodyPRKD1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Protein Kinase D1 (PRKD1) (AA 1-912) antibodyPRKD1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Protein Kinase D1 (PRKD1) (AA 361-389), (N-Term) antibodyPRKD1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB1037 unconjugated
anti-Protein Kinase D1 (PRKD1) (AA 171-220) antibodyPRKD1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1,0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- DO NOT FREEZE!
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- PKC mu (PRKD1) (Protein Kinase D1 (PRKD1))
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别名
- PRKD1
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背景
- Protein Kinase C mu, is a ~140 kDa member of the novel group (nPKCs: sensitive to diacylglycerol, phosphatidylserine, and phorbol esters) of the PKC family of serine/threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival, metastasis and transcriptional regulation. PKC mu (also known as Protein Kinase D or PKD) is implicated in the regulation of multiple cellular processes including Golgi organization and membrane transport in epithelial cells. PKC mu is phosphorylated on serine 742 (serine 748 for the mouse sequence) in the activation loop in a PKC-dependent pathway, mainly by PKC eta and PKC epsilon. This is critical for its catalytic activity, substrate phosphorylation and role in activating the ERK1 MAP Kinase signaling cascade. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes.Synonyms: PKC D1, PKC mu, PKD, PKD1, PRKCM, Protein kinase C mu type, Protein kinase D, Serine/threonine-protein kinase D1, nPKC-D1, nPKC-mu
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分子量
- approx. 100 to 140 kDa
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基因ID
- 5587
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NCBI登录号
- NP_002733
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UniProt
- Q15139
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途径
- Myometrial Relaxation and Contraction
抗原
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