PBK 抗体
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北京 101111
Quick Overview for PBK 抗体 (ABIN272056)
抗原
See all PBK 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of PBK/TOPK protein. (region surrounding Ile4)
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交叉反应 （详细）
- Species reactivity (tested):Human.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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纯度
- > 95 % pure by SDS-PAGE
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anti-PDZ Binding Kinase (PBK) antibody
PBK 适用: 人 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 2C8 unconjugated
anti-PDZ Binding Kinase (PBK) (AA 1-110) antibodyPBK 适用: 人 WB, ELISA, IHC (p), IF 宿主: 小鼠 Monoclonal 3A11 unconjugated
anti-PDZ Binding Kinase (PBK) (AA 1-322) antibodyPBK 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-PDZ Binding Kinase (PBK) (AA 1-322) antibodyPBK 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2D6 unconjugated
anti-PDZ Binding Kinase (PBK) (AA 1-110) antibodyPBK 适用: 人 WB, ELISA, IHC (p), IF 宿主: 小鼠 Monoclonal 4A10 unconjugated
anti-PDZ Binding Kinase (PBK) (AA 71-322) antibodyPBK 适用: 人, 小鼠, 大鼠 WB, IHC, IF, FACS, ICC 宿主: 兔 Polyclonal unconjugated
anti-PDZ Binding Kinase (PBK) (AA 58-86), (N-Term) antibodyPBK 适用: 人, 小鼠 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB40570 unconjugated
anti-PDZ Binding Kinase (PBK) (AA 122-229) antibodyPBK 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2A3 unconjugated
anti-PDZ Binding Kinase (PBK) (AA 251-322) antibodyPBK 适用: 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-PDZ Binding Kinase (PBK) (AA 1-322) antibodyPBK 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1: 21000approx. 1: 5000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should bedetermined by the user. -
限制
- 仅限研究用
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浓度
- 1,0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- DO NOT FREEZE!
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- PBK (PDZ Binding Kinase (PBK))
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别名
- PBK / TOPK
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背景
- PBK (PDZ binding kinase) belongs to the serine/threonine protein kinase family. It is related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family and phosphorylates MAP kinase p38. It is active only in mitosis. When phosphorylated it forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. It makes a kinase-substrate complex with cdk1/cyclin B1 and PRC1 on microtubules during mitosis, enhances the cdk1/cyclin B1-dependent phosphorylation of PRC1 and thereby strongly promotes cytokinesis. It may play a role in the activation of lymphoid cells.Synonyms: CT84, Cancer/testis antigen 84, Lymphokine-activated killer T-cell-originated protein kinase, MAPKK-like protein kinase, Nori-3, PDZ-binding kinase, SPK, T-LAK cell-originated protein kinase
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分子量
- approx. 36 kDa
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基因ID
- 55872
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NCBI登录号
- NP_060962
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UniProt
- Q96KB5
抗原
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