PIAS3 抗体
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北京 101111
Quick Overview for PIAS3 抗体 (ABIN271953)
抗原
See all PIAS3 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of PIAS3 protein. (region surrounding Phe25)
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交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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纯度
- > 95 % pure by SDS-PAGE
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anti-Protein Inhibitor of Activated STAT, 3 (PIAS3) (N-Term) antibody
PIAS3 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 3 (PIAS3) (AA 453-550) antibodyPIAS3 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 4F12 unconjugated
anti-Protein Inhibitor of Activated STAT, 3 (PIAS3) (AA 452-628) antibodyPIAS3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 3 (PIAS3) (AA 95-126), (N-Term) antibodyPIAS3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB0671 unconjugated
anti-Protein Inhibitor of Activated STAT, 3 (PIAS3) (AA 588-619) antibodyPIAS3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB0673 unconjugated
anti-Protein Inhibitor of Activated STAT, 3 (PIAS3) (N-Term) antibodyPIAS3 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 3 (PIAS3) (AA 548-597) antibodyPIAS3 适用: 人, 大鼠, 犬, Cow, Pig, 马, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 3 (PIAS3) (N-Term) antibodyPIAS3 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 3 (PIAS3) (AA 399-628) antibodyPIAS3 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 3 (PIAS3) (C-Term) antibodyPIAS3 适用: 人, 大鼠, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1,0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- DO NOT FREEZE!
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- PIAS3 (Protein Inhibitor of Activated STAT, 3 (PIAS3))
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别名
- PIAS3
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背景
- The IL-6 type family of cytokines, which includes IL-6 as well as a number of similar cytokines and growth factors, plays a significant role in regulating gene activation, proliferation and differentiation. Transcription factors of the Stat family are known to be involved in this signal transduction pathway, undergoing phosphorylation, dimerization, and translocation to the nucleus upon activation. PIAS 1, for protein inhibitor of activated Stat1 (also designated Gu/RNA helicase II binding protein), binds specifically to Stat1, blocking Stat1 DNA-binding activity and inhibiting Stat1-mediated gene activation. PIAS 1 also binds to the Gu/RNA helicase II enzyme, leading to the proteolytic cleavage of Gu/RH-II. PIAS 3 similarly binds specifically to Stat3, blocking Stat3 DNA-binding activity and inhibiting Stat3-mediated gene activation.Synonyms: E3 SUMO-protein ligase PIAS3, Protein inhibitor of activated STAT protein 3
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分子量
- approx. 68 kDa
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基因ID
- 10401
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NCBI登录号
- NP_006090
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UniProt
- Q9Y6X2
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途径
- JAK/STAT Signaling
抗原
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