FOXO1/3/4-pan 抗体
The 兔 多克隆 anti-FOXO1/3/4-pan antibody is suitable to detect FOXO1/3/4-pan in samples from 人, 小鼠 和 大鼠. It has been validated for IHC (p).
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产品编号 ABIN271928
发货至:
中国
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北京 101111
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Quick Overview for FOXO1/3/4-pan 抗体 (ABIN271928)
抗原
FOXO1/3/4-pan (FOXO1/3/4)
(Forkhead Box O1/3/4 (FOXO1/3/4))
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
This FOXO1/3/4-pan antibody is un-conjugated
应用范围
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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特异性
- This antibody detects endogenous levels of FOXO1/3/4-pan protein. (region surrounding Pro18/26)
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交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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纯度
- > 95 % pure by SDS-PAGE
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anti-Forkhead Box O1/3/4 (FOXO1/3/4) (pThr24), (pThr32) antibody
FOXO1/3/4 适用: 人, 小鼠, 大鼠 IHC, ELISA, WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1: 1000approx. 1: 5000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1,0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- DO NOT FREEZE!
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- FOXO1/3/4-pan (FOXO1/3/4) (Forkhead Box O1/3/4 (FOXO1/3/4))
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别名
- FOXO1/3/4-Pan
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背景
- FOXO1 + FOX3 + FOX4 belong to the forkhead family of transcription factors. FOXO1 (FKHR or ForkHead in Rhabdomyosarcoma) is a 70 kDa protein. Recent studies have shown that this protein can act as either a coactivator or a corepressor of nuclear receptor activity. This action is mediated through the LXXLL motif found in the C terminus of the FOXO1A protein. The specific function of the gene has not yet been determined. FOX3 probably functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of the FOXO3 gene with the MLL gene is associated with secondary acute leukemia. FOX4 is a forkhead transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO4 down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle.Synonyms: FOXO1A, FOXO3A, FOXO4A, Forkhead Box Protein O1A, Forkhead in Rhabdomyosarcoma
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分子量
- approx. 70 to 82 kDa
抗原
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