Acetyl-CoA Carboxylase alpha 抗体
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Quick Overview for Acetyl-CoA Carboxylase alpha 抗体 (ABIN271866)
抗原
See all Acetyl-CoA Carboxylase alpha (ACACA) 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of Acetyl-CoA Carboxylase protein. (region surrounding His74)
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交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
纯化方法
- Affinity Chromatography using epitope-specific immunogen.
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anti-Acetyl-CoA Carboxylase alpha (ACACA) antibody
ACACA 适用: 人 WB, IHC, IP 宿主: 兔 Monoclonal unconjugated
anti-Acetyl-CoA Carboxylase alpha (ACACA) (pSer79) antibodyKD Validated ACACA 适用: 人 WB, IF (p) 宿主: 兔 Monoclonal 25GB2275 unconjugated Recombinant Antibody
anti-Acetyl-CoA Carboxylase alpha (ACACA) (pSer79) antibodyACACA 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Acetyl-CoA Carboxylase alpha (ACACA) (N-Term) antibodyACACA 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Acetyl-CoA Carboxylase alpha (ACACA) antibodyACACA 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Acetyl-CoA Carboxylase alpha (ACACA) antibodyACACA 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Acetyl-CoA Carboxylase alpha (ACACA) antibodyKD Validated ACACA 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB5645 unconjugated Recombinant Antibody
anti-Acetyl-CoA Carboxylase alpha (ACACA) (Ser122) antibodyACACA 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Acetyl-CoA Carboxylase alpha (ACACA) (AA 1-99) antibodyACACA 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6H5 unconjugated
anti-Acetyl-CoA Carboxylase alpha (ACACA) (pSer80) antibodyACACA 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1/5000-1/10000. Western blot: 1/500-1/1000. Immunohistochemistry: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Acetyl-CoA Carboxylase alpha (ACACA)
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别名
- Acetyl-CoA Carboxylase 1
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背景
- Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the ratelimiting step in fatty acid synthesis. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. ACC-alpha (ACC1) is the rate-limiting enzyme in the biogenesis of long-chain fatty acids, and ACC-beta (ACC2) may control mitochondrial fatty acid oxidation. These two isoforms of ACC control the amount of fatty acids in the cells. The catalytic function of ACC-alpha is regulated by phosphorylation (inactive) and dephosphorylation (active) of targeted Serine residues and by allosteric transformation by citrate or palmitoyl-CoA, which serve as the short-term regulatory mechanism of the enzyme. The gene encoding ACC-alpha, which maps to human chromosome 17, encodes the 265 kDa alpha form of ACC, which is the major ACC in lipogenic tissues. The catalytic core of ACC-beta is homologous to that of ACC-alpha except for an additional peptide of about 150 amino acids at the N-terminus.Synonyms: ACAC, ACACA, ACC1, ACCA
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分子量
- approx. 265 kDa
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基因ID
- 31
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NCBI登录号
- NP_942131
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UniProt
- Q13085
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途径
- AMPK Signaling, Ribonucleoside Biosynthetic Process, Warburg Effect
抗原
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