WNK1 抗体
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Quick Overview for WNK1 抗体 (ABIN271862)
抗原
See all WNK1 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of WNK1 protein. (region surrounding Tyr52)
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交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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纯度
- > 95 % pure by SDS-PAGE
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anti-WNK Lysine Deficient Protein Kinase 1 (WNK1) (pThr60) antibody
WNK1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 1 (WNK1) (N-Term) antibodyWNK1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 1 (WNK1) (AA 1-207) antibodyWNK1 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 1 (WNK1) (AA 1154-1195), (Middle Region) antibodyWNK1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 1 (WNK1) (AA 1954-2231) antibodyWNK1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 1 (WNK1) (Internal Region) antibodyWNK1 适用: 人, 小鼠, 大鼠, 马, 猴, 兔, Pig, Bat, Hamster, 小鸡, Cow IHC, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 1 (WNK1) (C-Term) antibodyWNK1 适用: 人, 小鼠, 大鼠, 马, 猴, 兔, Bat, Hamster IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 1 (WNK1) (AA 1-210) antibodyWNK1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 1 (WNK1) (AA 1848-1882) antibodyWNK1 适用: 人 WB 宿主: 兔 Polyclonal RB56242 unconjugated
anti-WNK Lysine Deficient Protein Kinase 1 (WNK1) (Tyr773) antibodyWNK1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1,0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- DO NOT FREEZE!
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- WNK1 (WNK Lysine Deficient Protein Kinase 1 (WNK1))
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别名
- WNK1
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背景
- The protein kinase superfamily contains over a thousand proteins in 57 subfamilies that all share a catalytic core of 250 - 300 amino acids organized in two domains. WNK kinases (With No lysine (K)) are serine-threonine protein kinases that contain a cysteine residue in place of a lysine residue in a family of proteins that traditionally contain a lysine following a short string of hydro-phobic residues. WNK kinases contain a lysine upstream of the traditional position, within a glycine string. This lysine functions as an anchor and orients ATP through interactions with the alpha and beta phosphoryl groups. The catalytic domains of WNK2, WNK3 and WNK4 are 95 % homologous to WNK1. Human WNK1 maps to chromosome 12p13 and encodes a 2382 protein that is primarily expressed in heart, kidney, muscle and distal nephron. Human WNK3 maps to chromosome Xp11.21-p11.23 and encodes a protein that is primarily expressed in brain. Human WNK4 maps to chromosome 17q21-q22 and encodes a 1243 amino acid protein that is expressed in kidney. Aberrant function of WNK kinases and their associated signaling pathways are implicated in hypertension, increased renal salt reabsorption, and impaired K+ and H+ excretion.Synonyms: Erythrocyte 65 kDa protein, KDP, KIAA0344, Kinase deficient protein, PRKWNK1, Protein kinase lysine-deficient 1, Protein kinase with no lysine 1, Serine/threonine-protein kinase WNK1, p65
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分子量
- approx. 230 kDa
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基因ID
- 65125
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NCBI登录号
- NP_001171914
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UniProt
- Q9H4A3
抗原
-
