Aminoacylase 1 抗体
Quick Overview for Aminoacylase 1 抗体 (ABIN2716053)
抗原
See all Aminoacylase 1 (ACY1) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
产品特性
- Homo sapiens aminoacylase 1 (ACY1), transcript variant 1
-
纯化方法
- Purified from mouse ascites fluids by affinity chromatography
-
免疫原
- Full length human recombinant protein of human ACY1 (NP_000657) produced in HEK293T cell.
-
亚型
- IgG1
-
-
-
-
应用备注
- WB 1:2000, FLOW 1:100,
-
说明
-
The concentration of the product may vary between diferrent lots.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 0.5-1.0 mg/mL
-
缓冲液
- PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
-
- Aminoacylase 1 (ACY1)
-
别名
- ACY1
-
背景
- This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18.
-
分子量
- 45.7 kDa
-
基因ID
- 95
-
NCBI登录号
- NM_000666
-
HGNC
- 95
抗原
-