SDC4 抗体
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北京 101111
Quick Overview for SDC4 抗体 (ABIN2689914)
抗原
See all SDC4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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产品特性
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The KY/8.2 mAb reacts with mouse syndecan-4, a cell-surface heparan sulfate proteoglycan. Although the ligand(s) for this molecule is unknown, syndecans are known to interact with the heparin-binding domain of growth factors, chemokines, and extracellular matrix components. Accordingly, heparin inhibits the binding of syndecan-4 to the pre-B cell line BC7.12. Syndecan-4 is localized to focal adhesions and binds protein-kinase Cα. Thus, it is involved in cytoskeletal organization and signaling. Syndecan-4 is expressed on stromal cells and B-lymphocyte precursors in bone marrow, in addition to most splenic B cells and a small population of T lymphocytes. It is highly expressed on activated B lymphocytes, but is downregulated in isotype-switched memory B cells. The ectodomain of syndecan-4 is shed from cell surfaces constitutively and in response to specific physiological signals, and the resulting soluble fragments are functional. Immobilized KY/8.2 mAb induced the formation of dendritic processes on syndecan-4-transfected cells and on anti-CD40-activated splenic B cells. Other methods of activating B cells have not produced the same effect. This antibody recognizes an epitope in the N-terminus of syndecan-4, regardless of post-translational modifications.
BD Pharmingen™ Purified Rat Anti-Mouse Syndecan-4 - Purified - Clone KY/8.2 - Isotype Rat IgG2a, κ - Reactivity Ms - 0.1 mg -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- BCB10 mouse pre-B cell line
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亚型
- IgG2a kappa
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anti-Syndecan 4 (SDC4) (AA 19-145) antibody
SDC4 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Syndecan 4 (SDC4) (Ser179) antibodySDC4 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Syndecan 4 (SDC4) (C-Term) antibodySDC4 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Syndecan 4 (SDC4) (AA 1-198) antibodySDC4 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Syndecan 4 (SDC4) (AA 145-194) antibodySDC4 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Syndecan 4 (SDC4) (AA 101-198) antibodySDC4 适用: 人, Cow WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Syndecan 4 (SDC4) (AA 18-145) antibodySDC4 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Syndecan 4 (SDC4) (AA 20-147) antibodySDC4 适用: 小鸡 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Syndecan 4 (SDC4) (Tyr1022) antibodySDC4 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Syndecan 4 (SDC4) (AA 1-198) antibodySDC4 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store undiluted at 4°C.
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: "Syndecan-4 and focal adhesion function." in: Current opinion in cell biology, Vol. 13, Issue 5, pp. 578-83, (2001) (PubMed).
: "Shedding of syndecan-1 and -4 ectodomains is regulated by multiple signaling pathways and mediated by a TIMP-3-sensitive metalloproteinase." in: The Journal of cell biology, Vol. 148, Issue 4, pp. 811-24, (2000) (PubMed).
: "Syndecan-4 is expressed by B lineage lymphocytes and can transmit a signal for formation of dendritic processes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 10, pp. 5940-8, (1999) (PubMed).
: "Molecular interactions of the syndecan core proteins." in: Current opinion in cell biology, Vol. 10, Issue 5, pp. 620-8, (1998) (PubMed).
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: "Syndecan-4 and focal adhesion function." in: Current opinion in cell biology, Vol. 13, Issue 5, pp. 578-83, (2001) (PubMed).
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- SDC4 (Syndecan 4 (SDC4))
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别名
- Syndecan-4
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途径
- Glycosaminoglycan Metabolic Process
抗原
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