Panendothelial Cell Antigen 抗体
This 大鼠 单克隆 antibody specifically detects Panendothelial Cell Antigen in FACS, IHC (fro) 和 IHC (p). It exhibits reactivity toward 小鼠. It has been mentioned in 3+ publications
(3 references)
产品编号 ABIN2689874
发货至:
中国
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Quick Overview for Panendothelial Cell Antigen 抗体 (ABIN2689874)
抗原
Panendothelial Cell Antigen
适用
小鼠
宿主
大鼠
克隆类型
单克隆
应用范围
Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
克隆位点
MECA
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产品特性
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The MECA-32 antibody reacts with a dimer of 50-55- kDa subunits expressed on most or all endothelial cells in the embryonic and adult mouse, with the exception of cardiac and skeletal muscle and the brain. Normally in skeletal and cardiac muscle, MECA-32 antigen expression is limited to small arterioles and venules, however, under conditions of inflammation, it can be induced on previously non-expressing vessels in cardiac muscle. In the central nervous system (CNS), the panendothelial cell antigen expression is developmentally regulated. During embryonic development, the antigen is found on brain vasculature up to day 16 of gestation, after which it disappears. The cessation of MECA-32 antigen expression in the CNS may be associated with the establishment of the blood-brain barrier, which begins on day 16 of gestation. In the adult mouse, inflammation in the CNS can lead to re-expression of the panendothelial cell antigen. Immunohistochemical staining of mouse Panendothelial cell antigen: Frozen sections of normal mouse small intestine were reacted with the anti-panendothelial cell antigen monoclonal antibody. Cells expressing this molecule can be identified by the brown labeling of their cell membranes. Amplification 20X.
BD Pharmingen™ Purified Rat Anti-Mouse Panendothelial Cell Antigen - Purified - Clone MECA-32 - Isotype Rat IgG2a, κ - Reactivity Ms - 1 mL -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Mouse lymph node stromal cells
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亚型
- IgG2a kappa
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 31.25 μg/mL
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缓冲液
- Aqueous buffered solution containing BSA, goat serum, and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store undiluted at 4°C.
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: "Cell adhesion molecules on vessels during inflammation in the mouse central nervous system." in: Journal of neuroimmunology, Vol. 51, Issue 2, pp. 199-208, (1994) (PubMed).
: "Treatment of mice with anti-CD3 mAb induces endothelial vascular cell adhesion molecule-1 expression." in: Transplantation, Vol. 57, Issue 5, pp. 711-7, (1994) (PubMed).
: "Inducible expression of an endothelial cell antigen on murine myocardial vasculature in association with interstitial cellular infiltration." in: Transplantation, Vol. 48, Issue 5, pp. 874-7, (1989) (PubMed).
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- Panendothelial Cell Antigen
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背景
- Synonyms: Plvap, Pv1, MECA32, Plasmalemma vesicle-associated protein
抗原
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