CD207 抗体
(5 references)Quick Overview for CD207 抗体 (ABIN2689803)
抗原
See all CD207 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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品牌
- BD Pharmingen™
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产品特性
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The 2G3 monoclonal antibody specifically binds to Langerin which is also known as CD207 or C-type lectin domain family 4 member K (CLEC4K). CD207 is a 48 kDa type II transmembrane glycoprotein that belongs to the C-type lectin family. CD207 is selectively expressed by Langerhans cells, an immature dendritic cell type that is found in the epidermis and mucosal epithelia, and by some other dendritic cell subsets. CD207 is expressed on the cell surface membrane and by intracellular Birbeck granules whose formation depends on CD207. CD207 binds to certain surface carbohydrates that are expressed by microbes. It appears to play a role in the uptake of these microbes for subsequent processing and microbial antigen presentation to T cells. Immunohistochemical analysis of Langerin (CD207) expression by Langerhans cells within human skin. Acetone-fixed, frozen huma skin sections were stained with either Purified Mouse IgG1 κ Isotype Control (Cat. No. 550878, Left Image) or Purified Mouse Anti-Human Langerin (CD207) antibody (Cat. No. 564789, Right Image). A three-step staining procedure that employed Biotin Goat Anti-Mouse Ig (Cat. No. 550337), Streptavidin-Horseradish Peroxidase (HRP) (Cat. No. 550946), and the DAB Substrate Kit (Cat. No. 550880) was used to develop the primary staining reagents. Original magnification: 40x.
BD Pharmingen™ Purified Mouse Anti-Human Langerin (CD207) - Purified - Clone 2G3 (also known as AB5_8.2G3.6 ) - Isotype Mouse IgG1, λ - Reactivity Hu - 0.1 mg -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Human Langerin Recombinant Protein
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亚型
- IgG1 lambda
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anti-CD207 Molecule, Langerin (CD207) (AA 155-328) antibody
CD207 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 1C5A1 unconjugated
anti-CD207 Molecule, Langerin (CD207) (AA 1-328) antibodyCD207 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-CD207 Molecule, Langerin (CD207) antibodyCD207 适用: 人, Non-Human Primate ELISA, FACS, ICC, IHC (fro) 宿主: 小鼠 Monoclonal 2G3 unconjugated
anti-CD207 Molecule, Langerin (CD207) (AA 74-213) antibodyCD207 适用: 人 WB, ELISA, Coat 宿主: 小鼠 Monoclonal LGRN-1821 unconjugated
anti-CD207 Molecule, Langerin (CD207) antibodyCD207 适用: 人 IHC, IHC (p), HIER 宿主: 小鼠 Monoclonal 12D6 unconjugated
anti-CD207 Molecule, Langerin (CD207) (AA 161-260) antibodyCD207 适用: 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-CD207 Molecule, Langerin (CD207) (Internal Region) antibodyCD207 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-CD207 Molecule, Langerin (CD207) (AA 1-328) antibodyCD207 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-CD207 Molecule, Langerin (CD207) (AA 74-213) antibodyCD207 适用: 人 ELISA, Coat 宿主: 兔 Monoclonal LGRN-3136R unconjugated Recombinant Antibody
anti-CD207 Molecule, Langerin (CD207) (AA 74-213) antibodyCD207 适用: 人 WB, ELISA, Coat 宿主: 小鼠 Monoclonal rLGRN-1821 unconjugated Recombinant Antibody
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store undiluted at 4°C.
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: "E-cadherin interactions are required for Langerhans cell differentiation." in: European journal of immunology, Vol. 43, Issue 1, pp. 270-80, (2013) (PubMed).
: "Noncovalent assembly of anti-dendritic cell antibodies and antigens for evoking immune responses in vitro and in vivo." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 189, Issue 5, pp. 2645-55, (2012) (PubMed).
: "Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responses." in: Immunity, Vol. 35, Issue 2, pp. 260-72, (2011) (PubMed).
: "Langerin is a natural barrier to HIV-1 transmission by Langerhans cells." in: Nature medicine, Vol. 13, Issue 3, pp. 367-71, (2007) (PubMed).
: "Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules." in: Immunity, Vol. 12, Issue 1, pp. 71-81, (2000) (PubMed).
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: "E-cadherin interactions are required for Langerhans cell differentiation." in: European journal of immunology, Vol. 43, Issue 1, pp. 270-80, (2013) (PubMed).
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- CD207 (CD207 Molecule, Langerin (CD207))
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别名
- Langerin CD207
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背景
- Synonyms: CLC4K, CLEC4K, C-type lectin domain family 4 member K
抗原
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