H2-M3 抗体
Cited in 5+ publications. This anti-H2-M3 antibody is a Armenian Hamster 单克隆 antibody detecting H2-M3 in FACS 和 IP. Suitable for 化学剂.
(5 references)
产品编号 ABIN2689549
发货至:
中国
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Quick Overview for H2-M3 抗体 (ABIN2689549)
抗原
H2-M3
(Histocompatibility 2, M Region Locus 3 (H2-M3))
适用
化学剂
宿主
Armenian Hamster
克隆类型
单克隆
应用范围
Flow Cytometry (FACS), Immunoprecipitation (IP)
克隆位点
130
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产品特性
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The hamster anti-mouse H2-M3 antibody (clone 130) reacts with the H2-M3 major histocompatibility complex (MHC) non-classical class Ib antigen. H2-M3 (M3) associates with β2-microglobulin and is capable of being expressed by most leukocytes. However, due to a lack of endogenous antigens, M3 has been reported to be undetectable on most cells. Its expression is induced by high-affinity N-formylated peptides from mitochondria, Listeria monocytogenes, and Mycobacterium tuberculosis. The induced expression of M3 is most efficient on antigen presenting cells. M3 presents antigen to cytotoxic T lymphocytes and may play a key role in protective immunity against the intracellular bacteria L. monocytogenes and M. tuberculosis. Furthermore, M3 is capable of presenting mitochondrial antigens for intrathymic positive selection of T-cell receptors which recognize those peptides. Upregulation of H2-M3 expression by exogenous N-formylated peptide. C57BL/6 splenocytes were cultured overnight in the absence (left panel) or presence (right panel) of N-
BD Pharmingen™ Purified Hamster Anti-Mouse H2-M3 - Purified - Clone 130 - Isotype Armenian Hamster IgG - Reactivity Ms - 0.1 mg -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Purified soluble complex of recombinant truncated M3 and beta2-microglobulin
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亚型
- IgG
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store undiluted at 4°C.
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: "Induction of M3-restricted cytotoxic T lymphocyte responses by N-formylated peptides derived from Mycobacterium tuberculosis." in: The Journal of experimental medicine, Vol. 193, Issue 10, pp. 1213-20, (2001) (PubMed).
: "Positive selection of an H2-M3 restricted T cell receptor." in: Immunity, Vol. 11, Issue 1, pp. 33-43, (1999) (PubMed).
: "Response to Listeria monocytogenes in mice lacking MHC class Ia molecules." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 9, pp. 5429-36, (1999) (PubMed).
: "H2-M3, a full-service class Ib histocompatibility antigen." in: Annual review of immunology, Vol. 15, pp. 851-79, (1997) (PubMed).
: "Antigen presentation by major histocompatibility complex class I-B molecules." in: Annual review of immunology, Vol. 12, pp. 839-80, (1994) (PubMed).
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: "Induction of M3-restricted cytotoxic T lymphocyte responses by N-formylated peptides derived from Mycobacterium tuberculosis." in: The Journal of experimental medicine, Vol. 193, Issue 10, pp. 1213-20, (2001) (PubMed).
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- H2-M3 (Histocompatibility 2, M Region Locus 3 (H2-M3))
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别名
- H2-M3
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物质类
- Chemical
抗原
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