Gp49 Receptor 抗体
This Armenian Hamster 单克隆 antibody specifically detects Gp49 Receptor in FACS, IP 和 ELISA. It exhibits reactivity toward 小鼠. It has been mentioned in 4+ publications
(4 references)
产品编号 ABIN2689526
发货至:
中国
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Quick Overview for Gp49 Receptor 抗体 (ABIN2689526)
抗原
Gp49 Receptor
适用
小鼠
宿主
Armenian Hamster
克隆类型
单克隆
应用范围
Flow Cytometry (FACS), Immunoprecipitation (IP), ELISA
克隆位点
H1-1
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产品特性
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The H1.1 antibody reacts with gp49B, a structural homolog of the human Killer Inhibitory Receptors (KIR), and with the truncated related molecule gp49A. The gp49 receptors are expressed on myeloid cells of adult bone marrow, spleen, and liver and fetal liver. They are not found on resting lymphoid cells, but their expression is upregulated on activated NK cells. gp49B is a member of the Ig superfamily containing two cytoplasmic ITIM (Immunoreceptor Tyrosine-based Inhibitory Motif) domains, while gp49A has no ITIM. Although its ligand is unknown, it is established that cross-linking of gp49B can suppress cell activation events.
BD Pharmingen™ Purified Hamster Anti-Mouse gp49 Receptor - Purified - Clone H1.1 - Isotype Armenian Hamster IgG3, κ - Reactivity Ms - 0.1 mg -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- gp49B-Fc fusion protein composed of extracelluar domain of gp49B
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亚型
- IgG3 kappa
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store undiluted at 4°C.
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: "The gp49A gene has extensive sequence conservation with the gp49B gene and provides gp49A protein, a unique member of a large family of activating and inhibitory receptors of the immunoglobulin ..." in: Immunogenetics, Vol. 50, Issue 5-6, pp. 286-94, (2000) (PubMed).
: "Inducible expression of the gp49B inhibitory receptor on NK cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 10, pp. 5215-20, (2000) (PubMed).
: "Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 3, pp. 1318-23, (1999) (PubMed).
: "Mouse natural killer cells express gp49B1, a structural homologue of human killer inhibitory receptors." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 158, Issue 1, pp. 13-7, (1997) (PubMed).
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- Gp49 Receptor
抗原
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