Disialoganglioside GD3 抗体
There are 5+ publications for this product available. The 小鼠 单克隆 anti-Disialoganglioside GD3 antibody is suitable to detect Disialoganglioside GD3 in samples from 人. It has been validated for CyTox, IHC (fro), FACS 和 IF.
(5 references)
产品编号 ABIN2689491
发货至:
中国
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Quick Overview for Disialoganglioside GD3 抗体 (ABIN2689491)
抗原
Disialoganglioside GD3
适用
人
宿主
小鼠
克隆类型
单克隆
应用范围
Cytotoxicity Test (CyTox), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunofluorescence (IF)
克隆位点
MB3-6
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产品特性
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Gangliosides are sialic-acid bearing glycolipids expressed on the surface of all mammalian cells, and are likely involved in mediating cell-substratum interactions. They are important target antigens for antibody mediated cytolysis of human melanoma and neuroblastoma cells. Human melanoma cells produce gangliosides GD2 and/or GD3 which are present in substratum-attached material, and may play a significant role in the melanoma metastatic phenotype. Ganglioside GD3 is a major surface marker on most human melanoma cells. MB3.6 has been used to localize GD3 in the plasma membrane and in focal adhesion plaques of human melanoma cells.
BD Pharmingen™ Purified Mouse Anti-Human Disialoganglioside GD3 - Purified - Clone MB3.6 - Isotype Mouse IgG3, κ - Reactivity Hu - 0.1 mg -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- FM9 human melamona cell line
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亚型
- IgG3 kappa
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store undiluted at 4°C.
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: "Disialoganglioside GD2 on human neuroblastoma cells: target antigen for monoclonal antibody-mediated cytolysis and suppression of tumor growth." in: Cancer research, Vol. 47, Issue 4, pp. 1098-104, (1987) (PubMed).
: "Disialogangliosides GD2 and GD3 are involved in the attachment of human melanoma and neuroblastoma cells to extracellular matrix proteins." in: The Journal of cell biology, Vol. 102, Issue 3, pp. 688-96, (1986) (PubMed).
: "Disialoganglioside GD3 on human melanoma serves as a relevant target antigen for monoclonal antibody-mediated tumor cytolysis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 82, Issue 15, pp. 5155-9, (1985) (PubMed).
: "Tumor-associated carbohydrate antigens." in: Annual review of immunology, Vol. 2, pp. 103-26, (1985) (PubMed).
: "Localization of the gangliosides GD2 and GD3 in adhesion plaques and on the surface of human melanoma cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 81, Issue 18, pp. 5767-71, (1984) (PubMed).
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- Disialoganglioside GD3
抗原
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