GP5 抗体
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北京 101111
Quick Overview for GP5 抗体 (ABIN2689254)
抗原
See all GP5 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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产品特性
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The 1C2 antibody reacts with CD42d (Platelet Glycoprotein V, GPV), a glycoprotein of 74 kDa in the mouse and 88 kDa in the rat. GPV noncovalently associates with GPIb (CD42b and c) and GPIX (CD42a) to form a receptor for von Willebrand factor on megakaryocytes and resting platelets. The binding sites for von Willebrand factor and thrombin have been localized to the GPIbachain (CD42b) of the GPIb-V-IX complex. GPV is cleaved by thrombin to release a 69- kDa soluble fragment, which contains the epitope recognized by mAb 1C2. The 1C2 antibody does not cross-react with human platelets nor with other hematopoietic cells of the mouse and rat. Anti-mouse CD41 mAb MWReg30 (Cat. No. 553848, for the FITC conjugate) may be used with mAb 1C2 to monitor mouse megakaryocyte maturation.
BD Pharmingen™ Purified Hamster Anti-Mouse and Rat CD42d - Purified - Clone 1C2 - Isotype Armenian Hamster IgG3, λ1 - Reactivity Ms, Rat - 0.5 mg -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- (C57BL/6 x DBA/2)F1 mouse platelets
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亚型
- IgG3 lambda
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anti-Glycoprotein V (Platelet) (GP5) (AA 17-242) antibody
GP5 适用: 人 WB, FACS 宿主: 兔 Polyclonal unconjugated
anti-Glycoprotein V (Platelet) (GP5) (AA 246-485) antibodyGP5 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Glycoprotein V (Platelet) (GP5) antibodyGP5 适用: 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Glycoprotein V (Platelet) (GP5) (Internal Region) antibodyGP5 适用: 小鼠, 人, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Glycoprotein V (Platelet) (GP5) (Internal Region) antibodyGP5 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Glycoprotein V (Platelet) (GP5) antibody (APC)GP5 适用: 小鼠 FACS 宿主: Armenian Hamster Monoclonal 1C2 APC
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store undiluted at 4°C.
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: "Characterization of monoclonal antibodies against mouse and rat platelet glycoprotein V (CD42d)." in: Hybridoma, Vol. 19, Issue 6, pp. 455-61, (2001) (PubMed).
: "Functional conservation of platelet glycoprotein V promoter between mouse and human megakaryocytes." in: Experimental hematology, Vol. 28, Issue 7, pp. 802-14, (2000) (PubMed).
: "Gene cloning of rat and mouse platelet glycoprotein V: identification of megakaryocyte-specific promoters and demonstration of functional thrombin cleavage." in: Blood, Vol. 89, Issue 9, pp. 3253-62, (1997) (PubMed).
: "Novel monoclonal antibody reactive with thrombin-sensitive 74-kDa glycoproteins present on platelets and megakaryocytes both from mouse and rat." in: Hybridoma, Vol. 14, Issue 4, pp. 361-7, (1996) (PubMed).
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: "Characterization of monoclonal antibodies against mouse and rat platelet glycoprotein V (CD42d)." in: Hybridoma, Vol. 19, Issue 6, pp. 455-61, (2001) (PubMed).
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- GP5 (Glycoprotein V (Platelet) (GP5))
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别名
- CD42d
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背景
- Synonyms: Platelet Glycoprotein V
抗原
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