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CD1d 抗体 (Biotin)

CD1D 适用: 小鼠 FACS, IF, IHC (fro) 宿主: 大鼠 Monoclonal 1B1 Biotin
产品编号 ABIN2689069
发货至: 中国
  • 抗原 See all CD1d (CD1D) 抗体
    CD1d (CD1D) (CD1d Molecule (CD1D))
    适用
    • 57
    • 34
    • 16
    • 4
    小鼠
    宿主
    • 59
    • 15
    • 11
    大鼠
    克隆类型
    • 61
    • 24
    单克隆
    标记
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    • 3
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    • 2
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    • 1
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    This CD1d antibody is conjugated to Biotin
    应用范围
    • 41
    • 35
    • 21
    • 11
    • 7
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))
    品牌
    BD Pharmingen™
    产品特性
    The 1B1 antibody reacts with CD1d, a 48- kDa glycoprotein with structural homology to the major histocompatibility complex (MHC) class I molecules. The structure, expression, and functions of CD1 antigens are complex and have been reviewed. mAb 1B1 detects CD1d at varying levels on most types of bone marrow and peripheral leukocytes and on epithelial, dendritic, and lymphoid cells in the thymus. It appears to recognize CD1d only in association with β2m. CD1d has been reported to be expressed by gastrointestinal tract epithelium and in the cytoplasm of hepatocytes as detected viaimmunohistochemical staining of frozen sections with mAb 3C11 (Cat. No. 559871, for the purified antibody), suggesting a possible role for CD1d in mucosal immunity. However, CD1d expression was not detectable, via flow cytometry, on intestinal epithelial cells in studies using the anti-CD1d mAbs 3C11, 1B1, and 9C7. The 1B1 antibody competes with mAb 3C11 in binding to mouse splenocytes. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature.

    BD Pharmingen™ Biotin Rat Anti-Mouse CD1d - Biotin - Clone 1B1 - Isotype Rat IgG2b, κ - Reactivity Ms - 0.5 mg
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Mouse Cd1.1 cDNA-transfected RMA-S mouse T lymphoma and mouse L929 cells
    克隆位点
    1B1
    亚型
    IgG2b kappa
    Top Product
    Discover our top product CD1D Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.
    储存条件
    4 °C
    储存方法
    Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
  • Prigozy, Naidenko, Qasba, Elewaut, Brossay, Khurana, Natori, Koezuka, Kulkarni, Kronenberg: "Glycolipid antigen processing for presentation by CD1d molecules." in: Science (New York, N.Y.), Vol. 291, Issue 5504, pp. 664-7, (2001) (PubMed).

    Porcelli, Modlin: "The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids." in: Annual review of immunology, Vol. 17, pp. 297-329, (1999) (PubMed).

    Szalay, Ladel, Blum, Brossay, Kronenberg, Kaufmann: "Cutting edge: anti-CD1 monoclonal antibody treatment reverses the production patterns of TGF-beta 2 and Th1 cytokines and ameliorates listeriosis in mice." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 12, pp. 6955-8, (1999) (PubMed).

    Brossay, Tangri, Bix, Cardell, Locksley, Kronenberg: "Mouse CD1-autoreactive T cells have diverse patterns of reactivity to CD1+ targets." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 8, pp. 3681-8, (1998) (PubMed).

    Amano, Baumgarth, Dick, Brossay, Kronenberg, Herzenberg, Strober: "CD1 expression defines subsets of follicular and marginal zone B cells in the spleen: beta 2-microglobulin-dependent and independent forms." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 4, pp. 1710-7, (1998) (PubMed).

    Roark, Park, Jayawardena, Kavita, Shannon, Bendelac: "CD1.1 expression by mouse antigen-presenting cells and marginal zone B cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 7, pp. 3121-7, (1998) (PubMed).

    Brossay, Jullien, Cardell, Sydora, Burdin, Modlin, Kronenberg: "Mouse CD1 is mainly expressed on hemopoietic-derived cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 3, pp. 1216-24, (1997) (PubMed).

    Sydora, Brossay, Hagenbaugh, Kronenberg, Cheroutre: "TAP-independent selection of CD8+ intestinal intraepithelial lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 156, Issue 11, pp. 4209-16, (1996) (PubMed).

    Bleicher, Balk, Hagen, Blumberg, Flotte, Terhorst: "Expression of murine CD1 on gastrointestinal epithelium." in: Science (New York, N.Y.), Vol. 250, Issue 4981, pp. 679-82, (1990) (PubMed).

  • 抗原
    CD1d (CD1D) (CD1d Molecule (CD1D))
    别名
    CD1d (CD1D 产品)
    别名
    CD1A antibody, R3 antibody, CD1D antibody, CD1D1 antibody, CD1d molecule antibody, CD1D antigen, d polypeptide antibody, CD1D antibody
    背景
    Synonyms: CD1.1, Ly-38
    途径
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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