CD1d 抗体
(9 references)Quick Overview for CD1d 抗体 (ABIN2689068)
抗原
See all CD1d (CD1D) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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品牌
- BD Pharmingen™
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产品特性
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The 1B1 antibody reacts with CD1d, a 48- kDa glycoprotein with structural homology to the major histocompatibility complex (MHC) class I molecules. The structure, expression, and functions of CD1 antigens are complex and have been reviewed. mAb 1B1 detects CD1d at varying levels on most types of bone marrow and peripheral leukocytes and on epithelial, dendritic, and lymphoid cells in the thymus. It appears to recognize CD1d only in association with β2m. CD1d has been reported to be expressed by gastrointestinal tract epithelium and in the cytoplasm of hepatocytes as detected viaimmunohistochemical staining of frozen sections with mAb 3C11 (Cat. No. 559871, for the purified antibody), suggesting a possible role for CD1d in mucosal immunity. However, CD1d expression was not detectable, via flow cytometry, on intestinal epithelial cells in studies using the anti-CD1d mAbs 3C11, 1B1, and 9C7. The 1B1 antibody competes with mAb 3C11 in binding to mouse splenocytes. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature.
BD Pharmingen™ Purified Rat Anti-Mouse CD1d - Purified - Clone 1B1 - Isotype Rat IgG2b, κ - Reactivity Ms - 0.5 mg -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Mouse Cd1.1 cDNA-transfected RMA-S mouse T lymphoma and mouse L929 cells
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亚型
- IgG2b kappa
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anti-CD1d Molecule (CD1D) (AA 56-271) antibody
CD1D 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-CD1d Molecule (CD1D) (AA 32-302) antibodyCD1D 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-CD1d Molecule (CD1D) antibodyCD1D 适用: 小鼠, 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-CD1d Molecule (CD1D) antibody (PE)CD1D 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal 51-1 PE
anti-CD1d Molecule (CD1D) (AA 20-190) antibodyCD1D 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-CD1d Molecule (CD1D) antibodyCD1D 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-CD1d Molecule (CD1D) (AA 1-335) antibodyCD1D 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-CD1d Molecule (CD1D) (Internal Region) antibodyCD1D 适用: 小鼠, 人, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-CD1d Molecule (CD1D) antibodyCD1D 适用: 人, Non-Human Primate FACS, WB, IP, IHC (fro) 宿主: 小鼠 Monoclonal 51-1 unconjugated
anti-CD1d Molecule (CD1D) (AA 64-298) antibodyCD1D 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store undiluted at 4°C.
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: "The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids." in: Annual review of immunology, Vol. 17, pp. 297-329, (1999) (PubMed).
: "CD1d-restricted immunoglobulin G formation to GPI-anchored antigens mediated by NKT cells." in: Science (New York, N.Y.), Vol. 283, Issue 5399, pp. 225-9, (1999) (PubMed).
: "Cutting edge: anti-CD1 monoclonal antibody treatment reverses the production patterns of TGF-beta 2 and Th1 cytokines and ameliorates listeriosis in mice." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 12, pp. 6955-8, (1999) (PubMed).
: "CD1.1 expression by mouse antigen-presenting cells and marginal zone B cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 7, pp. 3121-7, (1998) (PubMed).
: "CD1 expression defines subsets of follicular and marginal zone B cells in the spleen: beta 2-microglobulin-dependent and independent forms." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 4, pp. 1710-7, (1998) (PubMed).
: "Mouse CD1 is mainly expressed on hemopoietic-derived cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 3, pp. 1216-24, (1997) (PubMed).
: "CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides." in: Science (New York, N.Y.), Vol. 278, Issue 5343, pp. 1626-9, (1997) (PubMed).
: "TAP-independent selection of CD8+ intestinal intraepithelial lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 156, Issue 11, pp. 4209-16, (1996) (PubMed).
: "Expression of murine CD1 on gastrointestinal epithelium." in: Science (New York, N.Y.), Vol. 250, Issue 4981, pp. 679-82, (1990) (PubMed).
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: "The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids." in: Annual review of immunology, Vol. 17, pp. 297-329, (1999) (PubMed).
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- CD1d (CD1D) (CD1d Molecule (CD1D))
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别名
- CD1d
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背景
- Synonyms: CD1.1, Ly-38
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途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
抗原
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