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IL2RG 抗体 (Biotin)

IL2RG 适用: 小鼠 FACS, Neut, BR 宿主: 大鼠 Monoclonal TUGm2 Biotin
产品编号 ABIN2688956
发货至: 中国
  • 抗原 See all IL2RG 抗体
    IL2RG (Interleukin 2 Receptor, gamma (IL2RG))
    适用
    • 71
    • 26
    • 25
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    • 1
    小鼠
    宿主
    • 60
    • 10
    • 9
    大鼠
    克隆类型
    • 63
    • 16
    单克隆
    标记
    • 34
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    • 4
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    • 2
    • 2
    • 2
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    This IL2RG antibody is conjugated to Biotin
    应用范围
    • 54
    • 31
    • 28
    • 8
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Neutralization (Neut), Blocking Reagent (BR)
    品牌
    BD Pharmingen™
    产品特性
    The TUGm2 antibody reacts with Mouse CD132 which is also known as the common γ subunit (γc). The γc chain subunit is shared by the IL-2, IL-4, IL-7, IL-9, and IL-15 receptor complexes. The γc receptor is expressed constitutively at low levels by most lymphocytes, myeloid cells, embryonic thymocytes, and lymphoid cell lines. The γc receptor is a 75-80 kD transmembrane glycoprotein which mediates signal transducing activities of cytokine receptor complexes with which it is associated. TUGm2 antibody can significantly block the binding of and proliferative response to IL-4 by CTLL-2 cells. It can also inhibit binding to high-affinity IL-2 receptors expressed by CTLL-2 cells. By itself, the TUGm2 antibody reportedly fails to significantly inhibit CTLL-2 proliferative responses to IL-2. However, when added along with TM-β1 (Cat. No. 553359), specific for the mouse IL-2Rβ chain, TUGm2 was shown to synergistically reduce IL-2-driven CTLL-2 proliferative responses. TUGm2 can reduce the IL-7-induced proliferation of Con A-activated mouse splenocytes and the IL-7 responsive pre-B cell line, IxN/2b. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature.

    BD Pharmingen™ Biotin Rat Anti-Mouse CD132 - Biotin - Clone TUGm2 - Isotype Rat IgG2b, κ - Reactivity Ms - 0.5 mg
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    克隆位点
    TUGm2
    亚型
    IgG2b kappa
    Top Product
    Discover our top product IL2RG Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.
    储存条件
    4 °C
    储存方法
    Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
  • Kondo, Takeshita, Higuchi, Nakamura, Sudo, Nishikawa, Sugamura: "Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes." in: Science (New York, N.Y.), Vol. 263, Issue 5152, pp. 1453-4, (1994) (PubMed).

    Kondo, Takeshita, Ishii, Nakamura, Watanabe, Arai, Sugamura: "Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4." in: Science (New York, N.Y.), Vol. 262, Issue 5141, pp. 1874-7, (1994) (PubMed).

    Guesdon, Ternynck, Avrameas: "The use of avidin-biotin interaction in immunoenzymatic techniques." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 27, Issue 8, pp. 1131-9, (1979) (PubMed).

  • 抗原
    IL2RG (Interleukin 2 Receptor, gamma (IL2RG))
    别名
    CD132 (IL2RG 产品)
    别名
    Ab2-183 antibody, Cd132 antibody, CD132 antibody, CIDX antibody, IL-2RG antibody, IMD4 antibody, P64 antibody, SCIDX antibody, SCIDX1 antibody, [g]c antibody, gamma(c) antibody, gc antibody, interleukin 2 receptor subunit gamma antibody, interleukin 2 receptor subunit gamma L homeolog antibody, interleukin 2 receptor, gamma chain antibody, IL2RG antibody, il2rg.L antibody, Il2rg antibody
    背景
    Synonyms: Cytokine Common γ chain, γc
    途径
    JAK/STAT Signaling, Growth Factor Binding
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