IL2RG 抗体 (Biotin)
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北京 101111
Quick Overview for IL2RG 抗体 (Biotin) (ABIN2688956)
抗原
See all IL2RG 抗体适用
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应用范围
克隆位点
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产品特性
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The TUGm2 antibody reacts with Mouse CD132 which is also known as the common γ subunit (γc). The γc chain subunit is shared by the IL-2, IL-4, IL-7, IL-9, and IL-15 receptor complexes. The γc receptor is expressed constitutively at low levels by most lymphocytes, myeloid cells, embryonic thymocytes, and lymphoid cell lines. The γc receptor is a 75-80 kD transmembrane glycoprotein which mediates signal transducing activities of cytokine receptor complexes with which it is associated. TUGm2 antibody can significantly block the binding of and proliferative response to IL-4 by CTLL-2 cells. It can also inhibit binding to high-affinity IL-2 receptors expressed by CTLL-2 cells. By itself, the TUGm2 antibody reportedly fails to significantly inhibit CTLL-2 proliferative responses to IL-2. However, when added along with TM-β1 (Cat. No. 553359), specific for the mouse IL-2Rβ chain, TUGm2 was shown to synergistically reduce IL-2-driven CTLL-2 proliferative responses. TUGm2 can reduce the IL-7-induced proliferation of Con A-activated mouse splenocytes and the IL-7 responsive pre-B cell line, IxN/2b. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature.
BD Pharmingen™ Biotin Rat Anti-Mouse CD132 - Biotin - Clone TUGm2 - Isotype Rat IgG2b, κ - Reactivity Ms - 0.5 mg -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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亚型
- IgG2b kappa
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anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 51-150) antibody
IL2RG 适用: 人, 大鼠 WB, FACS, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 23-262) antibodyIL2RG 适用: 人 WB, FACS, ELISA 宿主: 小鼠 Monoclonal 4A8E5 unconjugated
anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 23-262) antibodyIL2RG 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4A8F2 unconjugated
anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 76-101), (N-Term) antibodyIL2RG 适用: 人 WB, FACS, IF 宿主: 兔 Polyclonal RB22117 unconjugated
anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 23-262) antibodyIL2RG 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 23-263) antibodyIL2RG 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 2 Receptor, gamma (IL2RG) antibody (APC)IL2RG 适用: 人, 犬 FACS 宿主: 大鼠 Monoclonal TUGh4 APC
anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 23-260) antibodyIL2RG 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 75-230) antibodyIL2RG 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 2 Receptor, gamma (IL2RG) (N-Term) antibodyIL2RG 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.
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储存条件
- 4 °C
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储存方法
- Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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: "Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes." in: Science (New York, N.Y.), Vol. 263, Issue 5152, pp. 1453-4, (1994) (PubMed).
: "Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4." in: Science (New York, N.Y.), Vol. 262, Issue 5141, pp. 1874-7, (1994) (PubMed).
: "The use of avidin-biotin interaction in immunoenzymatic techniques." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 27, Issue 8, pp. 1131-9, (1979) (PubMed).
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: "Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes." in: Science (New York, N.Y.), Vol. 263, Issue 5152, pp. 1453-4, (1994) (PubMed).
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- IL2RG (Interleukin 2 Receptor, gamma (IL2RG))
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别名
- CD132
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背景
- Synonyms: Cytokine Common γ chain, γc
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途径
- JAK/STAT Signaling, Growth Factor Binding
抗原
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