Asialoglycoprotein Receptor 1 抗体
(3 references)-
- 抗原 See all Asialoglycoprotein Receptor 1 (ASGR1) 抗体
- Asialoglycoprotein Receptor 1 (ASGR1)
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适用
- 人, 大鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Asialoglycoprotein Receptor 1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), BioImaging (BI)
- 品牌
- BD Pharmingen™
- 产品特性
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The 8D7 monoclonal antibody recognizes Asialoglycoprotein receptor 1 (ASGPR 1), also known as Hepatic lectin H1 (HL-1). ASGPR 1 is an approximately 42 kDA type II integral membrane protein that is expressed on the surface of hepatic cells. It is expressed by hepatocytes on the sinusoidal-lateral plasma membrane but not on the bile canalicular membrane. ASGPR 1 plays a role in serum glycoprotein homeostasis. It functions as a subunit of the Asialoglycoprotein receptor (ASGPR) complex that binds, internalizes, and transports various glycoproteins for lysosomal degradation. The receptor may also promote hepatic infection by the binding and uptake of various viruses. The immunogen used to generate the 8D7 hybridoma was rat liver membrane extracts. Rat ASGPR consists of three polypeptide subunits (Rat hepatic lectin 1-3 (RHL1-3). The 8D7 antibody has been shown to react with a subunit-specific epitope on RHL-1.
BD Pharmingen™ Purified Mouse Anti-ASGPR 1 - Purified - Clone 8D7 - Isotype Mouse IgG1, κ - Reactivity Hu, Rat - 0.1 mg - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Rat Liver membrane constituents
- 克隆位点
- 8D7
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product ASGR1 Primary Antibody
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anti-Asialoglycoprotein Receptor 1 (ASGR1) (Middle Region) antibody
ASGR1 适用: 人, 小鼠, 大鼠, Cow, Pig, 豚鼠, 马, Saccharomyces cerevisiae WB 宿主: 兔 Polyclonal unconjugated
anti-Asialoglycoprotein Receptor 1 (ASGR1) (N-Term) antibodyASGR1 适用: 人, 小鼠, 大鼠, Cow, Pig, 豚鼠, 马, Saccharomyces cerevisiae WB 宿主: 兔 Polyclonal unconjugated
anti-Asialoglycoprotein Receptor 1 (ASGR1) antibodyASGR1 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Asialoglycoprotein Receptor 1 (ASGR1) (AA 77-289) antibodyASGR1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Asialoglycoprotein Receptor 1 (ASGR1) (AA 80-281) antibodyASGR1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Asialoglycoprotein Receptor 1 (ASGR1) antibodyASGR1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Asialoglycoprotein Receptor 1 (ASGR1) (AA 1-150) antibodyASGR1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Asialoglycoprotein Receptor 1 (ASGR1) (AA 201-291) antibodyASGR1 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Asialoglycoprotein Receptor 1 (ASGR1) (AA 68-291) antibodyASGR1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Asialoglycoprotein Receptor 1 (ASGR1) (AA 100-149) antibodyASGR1 适用: 人, Cow, 犬 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Flow Cytometry System. Immunofluorescent Staining of ASGPR 1 in Human Hepatocellular Carcinoma (Hep G2) cells. Hep G2 cells (ATCC, HB-8065) were fixed with BD Cytofix™ Fixation Buffer and stained with Purified Mouse Anti-ASGPR 1 (pseudo-colored green) at 5 μg/mL. The second-step reagent was Alexa Fluor® 488 Goat Anti-Mouse IgG (Life Technologies), and counter-staining was with DAPI (4',6-Diamidino-2-phenylindole dihydrochloride, pseudo-colored blue). The images were captured on a BD Pathway™ 435 Cell Analyzer and merged using BD AttoVision™ Software.
- 限制
- 仅限研究用
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- 浓度
- 0.5 mg/mL
- 缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store undiluted at 4°C.
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: "Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development." in: Hepatology (Baltimore, Md.), Vol. 51, Issue 5, pp. 1754-65, (2010) (PubMed).
: "A monoclonal antibody to rat asialoglycoprotein receptor that recognizes an epitope specific to its major subunit." in: Hepatology research : the official journal of the Japan Society of Hepatology, Vol. 26, Issue 1, pp. 55-60, (2003) (PubMed).
: "Development of a monoclonal antibody identifying an antigen which is segregated to the sinusoidal and lateral plasma membranes of rat hepatocytes." in: Gastroenterologia Japonica, Vol. 21, Issue 3, pp. 238-44, (1986) (PubMed).
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: "Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development." in: Hepatology (Baltimore, Md.), Vol. 51, Issue 5, pp. 1754-65, (2010) (PubMed).
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- 抗原
- Asialoglycoprotein Receptor 1 (ASGR1)
- 别名
- ASGPR 1 (ASGR1 产品)
- 别名
- ASGR1 antibody, ASGPR antibody, ASGPR1 antibody, CLEC4H1 antibody, HL-1 antibody, Asgr antibody, Asgr-1 antibody, ASGR antibody, RATRHL1 antibody, RHL1 antibody, asialoglycoprotein receptor 1 antibody, LOC721786 antibody, ASGR1 antibody, LOC489461 antibody, Asgr1 antibody, LOC101116157 antibody
- 背景
- Synonyms: Asialoglycoprotein receptor 1, ASGR1, ASGP-R1, ASGPR 1, HL-1, CLEC4H1
- 途径
- Thyroid Hormone Synthesis
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