HIV-1 Tat 抗体
Quick Overview for HIV-1 Tat 抗体 (ABIN2669371)
抗原
See all HIV-1 Tat 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- Tat protein clade A and B, GSTTat fusion protein
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产品特性
- The HIV-1 regulatory protein tat is considered an attractive target for the development of a multicomponent vaccine against HIV-1 infection. The protein is well conserved among different isolates and thus may be less susceptible to mutation leading to the production of escape virus variants. Tat is produced early after infection and it's essential for virus replication and infectivity. Tat protein is also immunogenic and antibodies (Ab) against tat have been correlated with delayed disease progression and may exert protective effects inhibiting HIV replication. Moreover, Tat is efficiently taken up by monocyte-derived dendritic cells, promoting their maturation. Finally, murine vaccination with a biologically active tat protein has been shown to be safe and immunogenic.
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纯化方法
- Polyclonal immunoglobulins purified by affinity chromatography.
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免疫原
- Recombinant purified HIV-1 tat protein Clade B expressed in E. coli
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Supplied in 100 mM sodium citrate, 50 mM Tris and 0.05 % v/v glycerol
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储存条件
- 4 °C
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- HIV-1 Tat
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别名
- HIV1 Tat
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物质类
- Viral Protein
抗原
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