STAT5 A/B 抗体 (pTyr694, pTyr699)
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北京 101111
Quick Overview for STAT5 A/B 抗体 (pTyr694, pTyr699) (ABIN2668940)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pTyr694, pTyr699
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原理
- STAT5A/B phospho Tyr694/Tyr699 antibody (pAb)
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纯化方法
- Affinity Purified
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免疫原
- This STAT5A/B phospho Tyr694/Tyr699 antibody was raised against a peptide containing phospho Tyr694 of human STAT5A. Human STAT5B shares the identical sequence surrounding Tyr699.
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亚型
- IgG
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应用备注
- WB: 1:500 - 1:2,000 dilution
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage
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储存条件
- -20 °C
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储存方法
- Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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有效期
- 24 months
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: "Targeting growth hormone receptor in human melanoma cells attenuates tumor progression and epithelial mesenchymal transition via suppression of multiple oncogenic pathways." in: Oncotarget, Vol. 8, Issue 13, pp. 21579-21598, (2017) (PubMed).
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- STAT5 A/B
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别名
- STAT5A/B
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背景
- STAT5A/B (signal transducer and activator of transcription 5) is a member of the STAT family of transcription factors. STATs undergo serine and tyrosine phosphorylation in response to growth factor or cytokine signaling. This phosphorylation results in dimerization and translocation of STAT proteins to the nucleus. The STAT5 protein is expressed in most cell types and is activated by multiple cytokines and growth factors including: IFNA1, IL-10, IL-6, IL-11, IL-12, IL-2, EGF, among others. Other members of the STAT family include STAT1a, STAT2, STAT3, STAT4, STAT5A, STAT5B and STAT6.
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分子量
- 92 kDa
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基因ID
- 6776
抗原
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