WHSC1 抗体 (AA 1-647)
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Quick Overview for WHSC1 抗体 (AA 1-647) (ABIN2668917)
抗原
See all WHSC1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-647
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原理
- MMSET / WHSC1 antibody (mAb) (Clone 29D1)
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纯化方法
- Protein G Chromatography
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免疫原
- This MMSET / WHSC1 antibody was raised against a recombinant protein corresponding to amino acids 1-647 of human MMSET-I.
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亚型
- IgG2b
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anti-Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) (AA 1-647) antibody
WHSC1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) (AA 1-240) antibodyWHSC1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) antibodyWHSC1 适用: 人, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) (AA 1-44) antibodyWHSC1 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) (AA 219-268) antibodyWHSC1 适用: 人, 小鼠, 犬, 豚鼠, 马, 兔, 小鸡, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) (N-Term) antibodyWHSC1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) (N-Term) antibodyWHSC1 适用: 人, 小鼠, 大鼠, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) (N-Term) antibodyWHSC1 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- ICC/IF: 0.5 μg/mL dilution
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限制
- 仅限研究用
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浓度
- 1 μg/μL
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缓冲液
- Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage
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储存条件
- -20 °C
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储存方法
- Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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有效期
- 24 months
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: "NSD2 contributes to oncogenic RAS-driven transcription in lung cancer cells through long-range epigenetic activation." in: Scientific reports, Vol. 6, pp. 32952, (2016) (PubMed).
: "The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor." in: Blood, Vol. 111, Issue 6, pp. 3145-54, (2008) (PubMed).
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- WHSC1 (Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1))
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别名
- MMSET / WHSC1
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背景
- MMSET (Multiple Myeloma SET domain-containing protein) / WHSC1 (Wolf-Hirschhorn Syndrome Candidate 1, also known as NSD2, Nuclear Receptor binding SET domain protein 2, TRX5, Trithorax 5) is a SET domain-containing histone methyltransferase specific for lysine 36 of histone H3. The MMSET / WHSC1 gene is deleted in Wolf-Hirschhorn syndrome, a disorder characterized by developmental defects and mental retardation. In 15 % of patients with Multiple Myeloma (MM), a chromosomal translocation leads to MMSET / WHSC1 gene being aberrantly placed under the control of the IgH intronic u enhancer and expressed at very high levels. This event is apparently a key component in cellular transformation leading to MM. Reduction in MMSET / WHSC1 expression in a myeloma cell line suppressed its growth, suggesting a role for MMSET in maintaining the transformed state.
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分子量
- 88 & 157 kDa
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基因ID
- 7468
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NCBI登录号
- NP_001035889
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途径
- SARS-CoV-2 Protein Interactome
抗原
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