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Histone H4 抗体 (acLys16)

Name: Histone H4 抗体 (acLys16)
SKU: ABIN2668880
Availability: OutOfStock

This anti-Histone H4 antibody is a 兔多克隆 antibody detecting Histone H4 in WB, ChIP, DB 和 ChIP-seq. Suitable for 人, Saccharomyces cerevisiae 和 Drosophila melanogaster. This Primary Antibody has been cited in 15+ publications.

Histone H4K16ac antibody (pAb) tested by Western blot. (Histone H4 抗体 (acLys16))

Histone H4K16ac antibody (pAb) tested by dot blot analysis. (Histone H4 抗体 (acLys16))

Histone H4K16ac antibody (pAb) specificity tested by peptide array analysis. (Histone H4 抗体 (acLys16))

ChIP

ChIP-seq

ChIP

5 images

(15 references)

产品编号 ABIN2668880

发货至: 中国

Datasheet as PDF

Quick Overview for Histone H4 抗体 (acLys16) (ABIN2668880)

Key Features

High quality Histone H4 Primary Antibody for the detection of Histone H4.
Reliable product with high standard validation data

抗原

See all Histone H4 抗体

Histone H4

适用

人, Saccharomyces cerevisiae, Drosophila melanogaster

宿主

兔

克隆类型

多克隆

标记

This Histone H4 antibody is un-conjugated

应用范围

Western Blotting (WB), Chromatin Immunoprecipitation (ChIP), Dot Blot (DB), ChIP DNA-Sequencing (ChIP-seq)

Discover our top product Histone H4 Primary Antibody

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acLys16

纯化方法

None

免疫原

This Histone H4 acetylLys16 antibody was raised against a peptide including acetyllysine 16 of histone H4.

Product Specific Information

What can the Histone H4 Antibody ABIN2668880 be used for?

This polyclonal Histone H4 Antibody detects Histone H4. The Histone H4 Antibody has been validated for various applications and can be used for the detection of Histone H4 and derivatives by Western Blotting, Chromatin Immunoprecipitation, Dot Blot, ChIP DNA-Sequencing.

What validation data is available for this Histone H4 Antibody?

The Primary Antibody is referenced in 15 publications and is characterized by a proven, very high reliability. It has currently 5 product images that show its performance in a variety of applications. Histone H4 Antibody for the detection of Histone H4 and derivatives.

What is the function of Histone H4?

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails\; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated\; this record represents the centromeric copy. [provided by RefSeq, Jul 2008].
anti-Histone H4 (acLys12) antibody
适用: 人, 小鼠, 大鼠 WB, IHC, IF, ELISA, ICC 宿主: 兔 Polyclonal unconjugated

anti-Histone H4 (3meLys20) antibody
适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Histone H4 (acLys12) antibody
适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Histone H4 (acLys5) antibody
适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated

anti-Histone H4 (meLys20) antibody
适用: 人 WB, IHC, IF, DB 宿主: 兔 Polyclonal unconjugated

anti-Histone H4 (2meLys20) antibody
适用: 人 WB, IHC, IF, IP, ChIP, ChIP-seq 宿主: 兔 Polyclonal unconjugated

anti-Histone H4 (3meLys20) antibody
适用: 人 WB, IHC, IF, DB 宿主: 兔 Polyclonal unconjugated

anti-Histone H4 (acLys8) antibody
适用: 人 WB, IHC, IF, IP, ChIP, ChIP-seq 宿主: 兔 Polyclonal unconjugated

anti-Histone H4 (acLys16) antibody
适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Histone H4 (meLys20) antibody
适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilution should be determined by the investigator.

限制

仅限研究用
状态

Liquid

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

储存条件

-20 °C

储存方法

Antibodies in solution can be stored at -20 °C for 2 years.

有效期

6 months
Verrier, Taglini, Barrales, Webb, Urano, Braun, Bayne: "Global regulation of heterochromatin spreading by Leo1." in: Open biology, Vol. 5, Issue 5, (2015) (PubMed).

Sedic, Skibinski, Brown, Gallardo, Mulligan, Martinez, Keller, Glover, Richardson, Cowan, Toland, Ravichandran, Riethman, Naber, Näär, Blasco, Hinds, Kuperwasser: "Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence." in: Nature communications, Vol. 6, pp. 7505, (2015) (PubMed).

Korb, Herre, Zucker-Scharff, Darnell, Allis: "BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice." in: Nature neuroscience, Vol. 18, Issue 10, pp. 1464-73, (2015) (PubMed).

Froyd, Kapoor, Dietrich, Rusche: "The deacetylase Sir2 from the yeast Clavispora lusitaniae lacks the evolutionarily conserved capacity to generate subtelomeric heterochromatin." in: PLoS genetics, Vol. 9, Issue 10, pp. e1003935, (2013) (PubMed).

Wang, Tadeo, Hou, Tu, Thompson, Yates, Jia: "Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries." in: Genes & development, Vol. 27, Issue 17, pp. 1886-902, (2013) (PubMed).

Thijssen, Tobi, Balog, Schouten, Kremer, El Bouazzaoui, Henneman, Putter, Eline Slagboom, Heijmans, van der Maarel: "Chromatin remodeling of human subtelomeres and TERRA promoters upon cellular senescence: commonalities and differences between chromosomes." in: Epigenetics, Vol. 8, Issue 5, pp. 512-21, (2013) (PubMed).

Badeaux, Yang, Cardenas, Vemulapalli, Chen, Kusewitt, Richie, Li, Bedford: "Loss of the methyl lysine effector protein PHF20 impacts the expression of genes regulated by the lysine acetyltransferase MOF." in: The Journal of biological chemistry, Vol. 287, Issue 1, pp. 429-37, (2012) (PubMed).

Krogan, Hogan, Long: "APETALA2 negatively regulates multiple floral organ identity genes in Arabidopsis by recruiting the co-repressor TOPLESS and the histone deacetylase HDA19." in: Development (Cambridge, England), Vol. 139, Issue 22, pp. 4180-90, (2012) (PubMed).

Yuan, Rossetto, Mellert, Dang, Srinivasan, Johnson, Hodawadekar, Ding, Speicher, Abshiru, Perry, Wu, Yang, Zheng, Speicher, Thibault, Verreault, Johnson, Berger, Sternglanz, McMahon, Côté, Marmorstein: "MYST protein acetyltransferase activity requires active site lysine autoacetylation." in: The EMBO journal, Vol. 31, Issue 1, pp. 58-70, (2012) (PubMed).

Larsson, Ulfhammer, Magnusson, Bergh, Lunke, El-Osta, Medcalf, Svensson, Karlsson, Jern: "Role of histone acetylation in the stimulatory effect of valproic acid on vascular endothelial tissue-type plasminogen activator expression." in: PLoS ONE, Vol. 7, Issue 2, pp. e31573, (2012) (PubMed).

McCullough, Xu, Dent, Bekiranov, Roeder, Grant: "Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar ataxia type 7 (SCA7) astrocytes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 52, pp. 21319-24, (2012) (PubMed).

Liu, McConnell, Dixon, Calvi: "Analysis of model replication origins in Drosophila reveals new aspects of the chromatin landscape and its relationship to origin activity and the prereplicative complex." in: Molecular biology of the cell, Vol. 23, Issue 1, pp. 200-12, (2012) (PubMed).

Sotillo, Laver, Mellert, Schelter, Cleary, McMahon, Thomas-Tikhonenko: "Myc overexpression brings out unexpected antiapoptotic effects of miR-34a." in: Oncogene, Vol. 30, Issue 22, pp. 2587-94, (2011) (PubMed).

Regnard, Straub, Mitterweger, Dahlsveen, Fabian, Becker: "Global analysis of the relationship between JIL-1 kinase and transcription." in: PLoS genetics, Vol. 7, Issue 3, pp. e1001327, (2011) (PubMed).

Kumari, Biacsi, Usdin: "Repeat expansion affects both transcription initiation and elongation in friedreich ataxia cells." in: The Journal of biological chemistry, Vol. 286, Issue 6, pp. 4209-15, (2011) (PubMed).
抗原

Histone H4

分子量

8 kDa

基因ID

121504