Retinoic Acid Receptor gamma 抗体 (AA 428-441)
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Quick Overview for Retinoic Acid Receptor gamma 抗体 (AA 428-441) (ABIN2668712)
抗原
See all Retinoic Acid Receptor gamma (RARG) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 428-441
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原理
- RAR-gamma antibody (mAb) (Clone 4g-7A11)
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纯化方法
- Protein G Chromatography
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免疫原
- This RAR-g antibody was raised against a recombinant protein corresponding to amino acids 428-441 (F-region) of human RARg.
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亚型
- IgG1 kappa
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1 μg/μL
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缓冲液
- Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage
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储存条件
- -20 °C
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储存方法
- Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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有效期
- 24 months
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: "Retinoic acid receptor and retinoid X receptor subtype expression for the differential diagnosis of thyroid neoplasms." in: European journal of endocrinology / European Federation of Endocrine Societies, Vol. 160, Issue 4, pp. 631-8, (2009) (PubMed).
: "Expression of retinoid-X receptors (-alpha,-beta,-gamma) and retinoic acid receptors (-alpha,-beta,-gamma) in normal human skin: an immunohistological evaluation." in: The Histochemical journal, Vol. 29, Issue 2, pp. 127-33, (1997) (PubMed).
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- Retinoic Acid Receptor gamma (RARG) (Retinoic Acid Receptor, gamma (RARG))
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别名
- RAR-gamma
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背景
- Retinoic acid receptors (RAR) are nuclear receptors that are activated by both all-trans retinoic acid and 9-cis retinoic acid. There are three retinoic acid receptors (RAR), RAR-a, RAR-b and RAR-g. RAR-g has two splice isoforms. RAR-g heterodimerizes with RXR and in the absence of ligand, the RAR/RXR dimer binds to hormone response elements complexed with co-repressor protein. Binding of agonist ligands to RAR results in dissociation of co-repressor and recruitment of coactivator protein which in turn promotes transcription of the downstream target gene into mRNA and eventually protein.
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分子量
- 52 kDa
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基因ID
- 5916
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NCBI登录号
- NP_000957
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途径
- Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Cell Size
抗原
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