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HDAC3 抗体 (AA 411-428)

Name: HDAC3 抗体 (AA 411-428)
SKU: ABIN2668680
Availability: OutOfStock

This 小鼠单克隆 antibody specifically detects HDAC3 in WB 和 IP. It exhibits reactivity toward 人.It has been mentioned in 1 publication

(1 reference)

产品编号 ABIN2668680

发货至: 中国

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Quick Overview for HDAC3 抗体 (AA 411-428) (ABIN2668680)

抗原

See all HDAC3 抗体

HDAC3 (Histone Deacetylase 3 (HDAC3))

适用

人

宿主

小鼠

克隆类型

单克隆

标记

This HDAC3 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunoprecipitation (IP)

克隆位点

3G6

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抗原表位
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1

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1
AA 411-428

原理

HDAC3 antibody (mAb) (Clone 3G6)

纯化方法

Protein G Chromatography

免疫原

This HDAC3 antibody was raised against a synthetic peptide corresponding to amino acids 411-428 of human HDAC3.

亚型

IgG
anti-Histone Deacetylase 3 (HDAC3) (AA 299-428) antibody
HDAC3 适用: 人 WB, IHC, IF, IP, ChIP 宿主: 兔 Polyclonal unconjugated

anti-Histone Deacetylase 3 (HDAC3) (pSer424) antibody
HDAC3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Histone Deacetylase 3 (HDAC3) (C-Term) antibody
HDAC3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Histone Deacetylase 3 (HDAC3) (AA 411-428), (C-Term) antibody
HDAC3 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC, FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Histone Deacetylase 3 (HDAC3) (AA 319-428) antibody
HDAC3 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2A3 unconjugated

anti-Histone Deacetylase 3 (HDAC3) (AA 1-428) antibody
HDAC3 适用: 人 WB, ELISA, IHC, IF, ChIP 宿主: 兔 Polyclonal unconjugated

anti-Histone Deacetylase 3 (HDAC3) antibody
HDAC3 适用: 人, 小鼠, 大鼠, 犬, 小鸡 WB, IHC (p), IF (p) 宿主: 兔 Polyclonal unconjugated

anti-Histone Deacetylase 3 (HDAC3) (AA 1-428) antibody
HDAC3 适用: 人 ELISA, IF, IP 宿主: 小鼠 Monoclonal 2F9-4B7 unconjugated

anti-Histone Deacetylase 3 (HDAC3) (C-Term) antibody
HDAC3 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Histone Deacetylase 3 (HDAC3) antibody
KD Validated HDAC3 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB860 unconjugated Recombinant Antibody

应用备注

This antibody is also available as an AbFlex engineered recombinant antibody. For details on the corresponding AbFlex Recombinant Antibody, see Catalog No. 91199.

限制

仅限研究用
浓度

1 μg/μL

缓冲液

Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

储存条件

-20 °C

储存方法

Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

有效期

24 months
Mueller, Breuer, Schmitt, Walter, Evert, Wüllner: "CK2-dependent phosphorylation determines cellular localization and stability of ataxin-3." in: Human molecular genetics, Vol. 18, Issue 17, pp. 3334-43, (2009) (PubMed).
抗原

HDAC3 (Histone Deacetylase 3 (HDAC3))

别名

HDAC3

背景

HDAC3 (Histone Deacetylase 3) is a member of the class I mammalian histone deacetylases (HDACs) involved in regulating chromatin structure during transcription. These enzymes catalyze the removal of acetyl groups from lysine residues of histones and other cellular proteins. Lysine N-e-acetylation is a dynamic, reversible and tightly regulated protein and histone modification that plays a major role in regulation of gene expression in various cellular functions. It consists of the transfer of an acetyl moiety from an acetyl coenzyme A to the e-amino group of a lysine residue. In vivo, acetylation is controlled by the antagonistic activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs). The HDACs are grouped into four classes, on the basis of similarity to yeast counterparts: HDAC class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC6, HDAC7, 9 and 10), class III (SIRT1-7) and class IV (HDAC11). By forming multi-protein complexes with the co-repressors SMRT and N-CoR, HDAC3 regulates the transcription of a plethora of genes. A growing list of non-histone proteins extends the role of HDAC3 beyond transcriptional repression. HDAC1, HDAC2 and HDAC3 are also ubiquitously expressed and can deacetylate both H3 and H4 in free histones or nucleosome substrate.

分子量

50 kDa

基因ID

8841

NCBI登录号

NP_003874

途径

Neurotrophin Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development