SIRT2 抗体 (pSer331)
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Quick Overview for SIRT2 抗体 (pSer331) (ABIN2668611)
抗原
See all SIRT2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- pSer331
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原理
- SIRT2 phospho Ser331 antibody (mAb) (Clone 6B5)
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纯化方法
- Protein G Chromatography
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免疫原
- This antibody was raised against a synthetic peptide corresponding to human SIRT2 phosphorylated at Serine 331.
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亚型
- IgG2a
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anti-Sirtuin 2 (SIRT2) (AA 288-389) antibody
SIRT2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 2 (SIRT2) (AA 128-227) antibodySIRT2 适用: 人 WB, ELISA, IF, RNAi 宿主: 小鼠 Monoclonal 4B11 unconjugated
anti-Sirtuin 2 (SIRT2) (AA 165-187), (Middle Region) antibodySIRT2 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 2 (SIRT2) (AA 28-303) antibodySIRT2 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 2 (SIRT2) antibodySIRT2 适用: 人, 大鼠, 小鼠 WB, IF 宿主: 小鼠 Monoclonal 1D4-H11-H11 unconjugated
anti-Sirtuin 2 (SIRT2) (AA 65-340) antibodySIRT2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 2 (SIRT2) (AA 65-340) antibodySIRT2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 2 (SIRT2) (AA 275-389) antibodySIRT2 适用: 人 ELISA 宿主: 小鼠 Monoclonal 5H11H9 unconjugated
anti-Sirtuin 2 (SIRT2) (C-Term) antibodySIRT2 适用: 人, 大鼠, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 2 (SIRT2) (C-Term) antibodySIRT2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1 μg/μL
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缓冲液
- Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage
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储存条件
- -20 °C
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储存方法
- Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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有效期
- 24 months
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: "The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility." in: The Journal of cell biology, Vol. 180, Issue 5, pp. 915-29, (2008) (PubMed).
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- SIRT2 (Sirtuin 2 (SIRT2))
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别名
- SIRT2
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背景
- SIRT2 (sirtuin 2) is a member of the SIR2 / Sirtuin family of NAD-dependant deacetylase enzymes. It has multiple targets for deacetylation, including tubulin, P53, HOXA10, FOXO3A, P300, FOXO1. SIRT2 suppresses adipogenesis by deacetylating FOXO1, promoting the binding of FOXO1 to PPARg and subsequent repression of PPARg mediated transcriptional activation. Similar to SIRT1, SIRT2 also deacetylates H4AcK16 similar to SIRT1, SIRT2 deacetylates histone H4 at lysine 16. SIRT2 is present in the cytoplasm during most of the cell cycle except in the G2/M transition and in mitosis, where it is found in the nucleus and in contact with chromatin and required for exit from mitosis. Ser-331 is phosphorylated by the cyclin kinases Cdk2 and Cdk5 and this phosphorylation inhibits SIRT2's catalytic activity.
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分子量
- 40 & 43 kDa
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基因ID
- 22933
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NCBI登录号
- NP_036369
抗原
-
