HDAC11 抗体 (AA 238-251)
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Quick Overview for HDAC11 抗体 (AA 238-251) (ABIN2668595)
抗原
See all HDAC11 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 238-251
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原理
- HDAC11 antibody (pAb)
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纯化方法
- Affinity Purified
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免疫原
- This HDAC11 antibody was raised against a peptide corresponding to amino acid residues 238-251 of human HDAC11.
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亚型
- IgG
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应用备注
- WB: 1 - 3 μg/mL dilution For optimal results, primary antibody incubations should be performed at room temperature. The addition of 0.1 % Tween 20 to all blocking solutions may also reduce background. Individual optimization may be required.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 μg/μL
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缓冲液
- PBS containing 0.2 % gelatin and 0.05 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage
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储存条件
- 4 °C,-20 °C
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储存方法
- Some products may be shipped at room temperature. This will not affect their stability or performance. Store at 4°C for short term. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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有效期
- 24 months
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- HDAC11 (Histone Deacetylase 11 (HDAC11))
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别名
- HDAC11
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背景
- HDAC11 (Histone Deacetylase 11) is a member of the class IV mammalian histone deacetylases (HDACs) involved in regulating chromatin structure during transcription. These enzymes catalyze the removal of acetyl groups from lysine residues of histones and other cellular proteins. Lysine N-e-acetylation is a dynamic, reversible and tightly regulated protein and histone modification that plays a major role in regulation of gene expression in various cellular functions. It consists of the transfer of an acetyl moiety from an acetyl coenzyme A to the e-amino group of a lysine residue. In vivo, acetylation is controlled by the antagonistic activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs). The HDACs are grouped into four classes, on the basis of similarity to yeast counterparts: HDAC class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC6, HDAC7, 9 and 10), class III (SIRT1-7) and class IV (HDAC11). In humans, expression of HDAC11 is limited to only a few organs, including brain, heart, muscle and kidney, suggesting an important role of HDAC11 in those tissues.
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分子量
- 36 kDa
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基因ID
- 79885
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NCBI登录号
- NP_001129513
抗原
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