HIPK2 抗体 (AA 898-1051)
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Quick Overview for HIPK2 抗体 (AA 898-1051) (ABIN2668288)
抗原
See all HIPK2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 898-1051
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原理
- HIPK2 antibody (mAb) (Clone 3E9)
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纯化方法
- Protein G Chromatography
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免疫原
- This HIPK2 antibody was raised against a recombinant protein including amino acids 898-1051 of mouse HIPK2.
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亚型
- IgG
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1 μg/μL
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缓冲液
- Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage
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储存条件
- -20 °C
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储存方法
- Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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有效期
- 24 months
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: "Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals." in: Molecular and cellular biology, Vol. 26, Issue 7, pp. 2758-71, (2006) (PubMed).
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- HIPK2 (Homeodomain Interacting Protein Kinase 2 (HIPK2))
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别名
- HIPK2
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背景
- HIPK2 (Homeodomain Interacting Protein Kinase 2) is a serine/threonine kinase present in the nucleus that interacts with homeodomain transcription factors and acts as a co-repressor of transcription. It inhibits cell growth, as well as promotes apoptosis through the phosphorylation and subsequent degradation of the anti-apoptotic factor CTBP1. HIPK2 also phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity.
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分子量
- 130 kDa
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基因ID
- 28996
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NCBI登录号
- NP_034563
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途径
- Cell Division Cycle
抗原
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