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IL-22 抗体

This 大鼠 单克隆 anti-IL-22 antibody (Clone BL35175) specifically detects IL-22 in BCA. The antibody is reactive with 小鼠 samples.
产品编号 ABIN2666346
发货至: 中国
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Quick Overview for IL-22 抗体 (ABIN2666346)

抗原

See all IL-22 (IL22) 抗体
IL-22 (IL22) (Interleukin 22 (IL22))

适用

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小鼠

宿主

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大鼠

克隆类型

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单克隆

标记

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This IL-22 antibody is un-conjugated

应用范围

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Biochemical Assay (BCA)

克隆位点

BL35175
  • 交叉反应

    纯化方法

    The antibody was purified by affinity chromatography.

    亚型

    IgG2a kappa
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 浓度

    0.5 mg/mL

    缓冲液

    phosphate-buffered solution, pH 7.2, 0.09 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    储存方法

    Upon receipt, store undiluted between 2°C and 8°C.
  • 抗原

    IL-22 (IL22) (Interleukin 22 (IL22))

    别名

    IL-22

    背景

    IL-22, a cytokine structurally related to IL-10, was originally identified in the mouse as a gene induced by IL-9 in T cells and mast cells. IL-22 was initially designated as IL-TIF (IL10-related T cell-derived inducible factor). Mouse IL-TIF consists of 179 amino acids, including four cysteins, and has a predicted molecular weight of 20 kD. Biological activity of IL-22 is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein, IL-22BP, which shares sequence similarity with an extracellular region of IL-22R1 (sIL-22R1). Both chains of the IL-22R complex belong to the class II cytokine receptor families. Two types of IL-22-binding receptor have been discovered, a membrane-bound receptor and a soluble receptor, both encoded by different genes. IL-22 is produced by immune cells and acts on non-immune cells to regulate local tissue inflammation. As a product of the recently identified T helper 17 lineage of CD4(+) effector lymphocytes, IL-22 plays a critical role in mucosal immunity as well as in dysregulated inflammation observed in autoimmune diseases.
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