BCL11B 抗体
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北京 101111
Quick Overview for BCL11B 抗体 (ABIN2666299)
抗原
See all BCL11B 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应
- 小鼠, 斑马鱼
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交叉反应 (详细)
- Mouse, Zebrafish
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纯化方法
- Protein G affinity purified.
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亚型
- IgG
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- Hepes-buffered solution, pH 7.5, 0.02 % Sodium azide .
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储存条件
- 4 °C
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储存方法
- Upon receipt, store undiluted between 2°C and 8°C.
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- BCL11B (B-Cell CLL/lymphoma 11B (Zinc Finger Protein) (BCL11B))
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别名
- Bcl11b
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背景
- The transcription factor Bcl11b is expressed in thymus, mainly T cells. It is indispensable for T lineage development. When Bcl11b was deleted, T cells from all developmental stages acquired NK cell properties and concomitantly lost or decreased T cell-associated gene expression. These induced T-to-natural killer (ITNK) cells, which were morphologically and genetically similar to conventional NK cells, killed tumor cells in vitro, and effectively prevented tumor metastasis in vivo. Therefore, ITNKs may represent a new cell source for cell-based therapies.
抗原
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