LAT 抗体
Our Local Distributor
北京 101111
Quick Overview for LAT 抗体 (ABIN2666079)
抗原
See all LAT 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
无交叉反应
- 小鼠
-
纯化方法
- The antibody was purified by affinity chromatography.
-
亚型
- IgG1
-
-
anti-Linker For Activation of T Cells (LAT) antibody
LAT 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Linker For Activation of T Cells (LAT) (Cytoplasmic Domain) antibodyLAT 适用: 人 WB, IP, ICFC 宿主: 小鼠 Monoclonal LAT-01 unconjugated
anti-Linker For Activation of T Cells (LAT) (pTyr191) antibodyLAT 适用: 人 WB, ELISA, IHC, IP, IF 宿主: 兔 Monoclonal 2E4 unconjugated Recombinant Antibody
anti-Linker For Activation of T Cells (LAT) antibodyKD Validated LAT 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB4940 unconjugated Recombinant Antibody
anti-Linker For Activation of T Cells (LAT) (AA 1-233) antibodyLAT 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3B11-1D5 unconjugated
anti-Linker For Activation of T Cells (LAT) (AA 30-237) antibodyLAT 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Linker For Activation of T Cells (LAT) (pTyr161) antibodyLAT 适用: 人 ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Linker For Activation of T Cells (LAT) (Cytoplasmic Domain) antibodyLAT 适用: 人 WB, IHC, IP, IHC (p) 宿主: 小鼠 Monoclonal LAT1111 unconjugated
anti-Linker For Activation of T Cells (LAT) (AA 25-221) antibodyLAT 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Linker For Activation of T Cells (LAT) (AA 33-227) antibodyLAT 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
浓度
- 0.5 mg/mL
-
缓冲液
- phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide. Final antibody concentration is 0.5 mg/mL.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C
-
储存方法
- Upon receipt, store between 2°C and 8°C.
-
-
- LAT (Linker For Activation of T Cells (LAT))
-
别名
- LAT
-
背景
- LAT (linker for activation of T-cells) is a 36 kD phospho-tyrosine adaptor protein containing SH2 domains and a CVRC motif. Two LAT isoforms have been reported with approximate molecular weights of 36 kD and 38 kD. LAT is localized to lipid rafts, and is also a potential type III transmembrane protein, thought to be expressed in the juxtanuclear intracellular compartment. LAT links TCR engagement to Ras-MAPK activation, Ca2+ flux, IL-2 expression and is required for T-cell development. LAT is phosphorylated when activated by TCR cross-linking, where it recruits signaling molecules. LAT activation can be prevented by polyunsaturated fatty acids. LAT is modified by ZAP-70 and Syk phosphorylation and can also be palmitoylated. LAT has been reported to be associated with Grb2, Gads, Grap, PLC-γ1, p85 subunit PI3K, ZAP-70, Syk, Itk, Vav, SLP-76, and cbl.
-
途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway
抗原
-
